The WISP2 Polyclonal Antibody (CAB12541) is a valuable tool for researchers studying WISP2, a protein involved in various cellular processes such as cell proliferation, migration, and differentiation. This antibody, produced through immunization of rabbits, exhibits high specificity and sensitivity towards human samples, making it ideal for Western blot applications. By binding specifically to the WISP2 protein, this antibody enables accurate detection and analysis of WISP2 in a variety of cell types.WISP2, also known as CCN5, is a member of the CCN family of matricellular proteins that play crucial roles in tissue development, wound healing, and cancer progression.
Its involvement in diverse biological pathways makes it a key target for research in fields such as cell biology, developmental biology, and oncology. Understanding the functions and regulatory mechanisms of WISP2 can provide valuable insights into disease mechanisms and potential therapeutic strategies.Investigating the role of WISP2 using the CAB12541 Polyclonal Antibody can facilitate the exploration of WISP2's impact on various physiological and pathological processes. This antibody's reliability and accuracy make it a valuable asset for scientists seeking to elucidate the functions and molecular pathways associated with WISP2 in health and disease.
Product Name:
WISP2 Rabbit Polyclonal Antibody
SKU:
CAB12541
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 151-250 of human WISP2 (NP_003872.1).
This gene encodes a member of the WNT1 inducible signaling pathway (WISP) protein subfamily, which belongs to the connective tissue growth factor (CTGF) family. WNT1 is a member of a family of cysteine-rich, glycosylated signaling proteins that mediate diverse developmental processes. The CTGF family members are characterized by four conserved cysteine-rich domains: insulin-like growth factor-binding domain, von Willebrand factor type C module, thrombospondin domain and C-terminal cystine knot-like (CT) domain. The encoded protein lacks the CT domain which is implicated in dimerization and heparin binding. It is 72% identical to the mouse protein at the amino acid level. This gene may be downstream in the WNT1 signaling pathway that is relevant to malignant transformation. Its expression in colon tumors is reduced while the other two WISP members are overexpressed in colon tumors. It is expressed at high levels in bone tissue, and may play an important role in modulating bone turnover.
Purification Method:
Affinity purification
Gene ID:
8839
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Immunofluorescence analysis of A-549 cells using WISP2 Rabbit pAb (CAB12541) at dilution of 1:100 (40x lens). Blue: DAPI for nuclear staining.
