WISP1 Antibody (PACO20881)
- SKU:
- PACO20881
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Frequently bought together:
Description
WISP1 Antibody (PACO20881)
The WISP1 Polyclonal Antibody (PAC020881) is a valuable tool for research involving WISP1, a member of the CCN family of secreted proteins that play a role in cell proliferation, migration, and tissue regeneration. This antibody, raised in rabbits, has high reactivity with human samples and is suitable for use in Western blot and immunohistochemistry applications. It specifically binds to the WISP1 protein, allowing for detection and analysis in a variety of cell types.WISP1, also known as CCN4, has been implicated in various biological processes, including wound healing, fibrosis, and tumorigenesis.
Its expression is elevated in many types of cancer, making it a potential target for cancer therapy. Research into the function of WISP1 is essential for understanding its role in disease progression and developing novel therapeutic strategies.Overall, the WISP1 Polyclonal Antibody is a valuable tool for researchers studying the biological functions of WISP1 and its potential implications in cancer and other diseases. Its high specificity and reactivity make it a reliable choice for studies in cell biology, oncology, and regenerative medicine.
| Antibody Name: | WISP1 Antibody (PACO20881) |
| Antibody SKU: | PACO20881 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:5000, IHC:1:25-1:100 |
| Species Reactivity: | Human, Mouse, Rat |
| Immunogen: | Synthetic peptide of human WISP1 |
| Form: | Liquid |
| Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| Purification Method: | Antigen affinity purification |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO20881(WISP1 Antibody) at dilution 1/25, on the right is treated with synthetic peptide. (Original magnification: x200). |
 | The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using PACO20881(WISP1 Antibody) at dilution 1/25, on the right is treated with synthetic peptide. (Original magnification: x200). |
| Background: | This gene encodes a member of the WNT1 inducible signaling pathway (WISP) protein subfamily, which belongs to the connective tissue growth factor (CTGF) family. WNT1 is a member of a family of cysteine-rich, glycosylated signaling proteins that mediate diverse developmental processes. The CTGF family members are characterized by four conserved cysteine-rich domains: insulin-like growth factor-binding domain, von Willebrand factor type C module, thrombospondin domain and C-terminal cystine knot-like domain. This gene may be downstream in the WNT1 signaling pathway that is relevant to malignant transformation. It is expressed at a high level in fibroblast cells, and overexpressed in colon tumors. The encoded protein binds to decorin and biglycan, two members of a family of small leucine-rich proteoglycans present in the extracellular matrix of connective tissue, and possibly prevents the inhibitory activity of decorin and biglycan in tumor cell proliferation. It also attenuates p53-mediated apoptosis in response to DNA damage through activation of the Akt kinase. It is 83% identical to the mouse protein at the amino acid, level. Multiple alternatively spliced transcript variants have been identified. |
| Synonyms: | WNT1 inducible signaling pathway protein 1 |
| UniProt Protein Function: | Downstream regulator in the Wnt/Frizzled-signaling pathway. Associated with cell survival. Attenuates p53-mediated apoptosis in response to DNA damage through activation of AKT kinase. Up-regulates the anti-apoptotic Bcl-X(L) protein. Adheres to skin and melanoma fibroblasts. In vitro binding to skin fibroblasts occurs through the proteoglycans, decorin and biglycan. |
| NCBI Summary: | This gene encodes a member of the WNT1 inducible signaling pathway (WISP) protein subfamily, which belongs to the connective tissue growth factor (CTGF) family. WNT1 is a member of a family of cysteine-rich, glycosylated signaling proteins that mediate diverse developmental processes. The CTGF family members are characterized by four conserved cysteine-rich domains: insulin-like growth factor-binding domain, von Willebrand factor type C module, thrombospondin domain and C-terminal cystine knot-like domain. This gene may be downstream in the WNT1 signaling pathway that is relevant to malignant transformation. It is expressed at a high level in fibroblast cells, and overexpressed in colon tumors. The encoded protein binds to decorin and biglycan, two members of a family of small leucine-rich proteoglycans present in the extracellular matrix of connective tissue, and possibly prevents the inhibitory activity of decorin and biglycan in tumor cell proliferation. It also attenuates p53-mediated apoptosis in response to DNA damage through activation of the Akt kinase. It is 83% identical to the mouse protein at the amino acid level. Multiple alternatively spliced transcript variants have been identified. [provided by RefSeq, Mar 2011] |
| UniProt Code: | O95388 |
| NCBI GenInfo Identifier: | 34098393 |
| NCBI Gene ID: | 8840 |
| NCBI Accession: | O95388.1 |
| UniProt Secondary Accession: | O95388,Q5JBS6, Q5JBS7, Q5JBS8, Q9HCS3, A8KAG6, E7EMM5 |
| UniProt Related Accession: | O95388 |
| Molecular Weight: | 21,550 Da |
| NCBI Full Name: | WNT1-inducible-signaling pathway protein 1 |
| NCBI Synonym Full Names: | WNT1 inducible signaling pathway protein 1 |
| NCBI Official Symbol: | WISP1Â Â |
| NCBI Official Synonym Symbols: | CCN4; WISP1c; WISP1i; WISP1tc  |
| NCBI Protein Information: | WNT1-inducible-signaling pathway protein 1 |
| UniProt Protein Name: | WNT1-inducible-signaling pathway protein 1 |
| UniProt Synonym Protein Names: | CCN family member 4; Wnt-1-induced secreted protein |
| Protein Family: | WNT1-inducible-signaling pathway protein |
| UniProt Gene Name: | WISP1Â Â |
| UniProt Entry Name: | WISP1_HUMAN |
| Antibodies | ELISA Kits |
| Anti-WISP1 Antibody (CAB3346) | Human WNT1-inducible-signaling pathway protein 1 (WISP1) ELISA Kit |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
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