The Wipi1 Polyclonal Antibody (CAB7528) is a valuable tool for researchers studying the WIPI1 protein, a key player in autophagy, a cellular process that degrades and recycles cellular components. This antibody, produced in rabbits, exhibits high reactivity with human samples and is validated for use in Western blot applications. By binding to WIPI1, this antibody allows for the detection and analysis of the protein in various cell types, making it an essential tool for studies in cell biology and disease research.WIPI1 is a crucial regulator of autophagy, a process essential for maintaining cellular health by recycling damaged organelles and proteins.
Dysregulation of autophagy has been linked to various diseases, including cancer, neurodegenerative disorders, and metabolic conditions. Understanding the role of WIPI1 in autophagy can provide valuable insights into disease mechanisms and therapeutic strategies targeting this pathway.Overall, the Wipi1 Polyclonal Antibody (CAB7528) is a reliable reagent for researchers seeking to investigate the function of WIPI1 in autophagy and its implications for disease pathology. Its specificity and sensitivity make it an indispensable tool for advancing our understanding of cellular processes and developing targeted therapies for autophagy-related disorders.
Product Name:
WIPI1 Rabbit Polyclonal Antibody
SKU:
CAB7528
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 187-446 of human WIPI1 (NP_060453.3).
This gene encodes a WD40 repeat protein. Members of the WD40 repeat family are key components of many essential biologic functions. They regulate the assembly of multiprotein complexes by presenting a beta-propeller platform for simultaneous and reversible protein-protein interactions. Members of the WIPI subfamily of WD40 repeat proteins have a 7-bladed propeller structure and contain a conserved motif for interaction with phospholipids. Alternative splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
55062
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using WIPI1 antibody (CAB7528) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 90s.
