The Whirlin Polyclonal Antibody (CAB10773) is a valuable tool for researchers studying the Whirlin protein, an essential component of the hair cell stereocilia in the inner ear. This antibody, produced in rabbits, is highly specific and reactive with human samples, making it ideal for use in immunofluorescence and immunohistochemistry applications.Whirlin plays a crucial role in the organization and maintenance of the hair bundle, which is responsible for detecting sound vibrations.
Mutations in the Whirlin gene have been linked to various forms of hearing loss, making it a focus of research in the field of auditory biology.By targeting the Whirlin protein, this antibody allows for the visualization and analysis of Whirlin expression in inner ear tissues, aiding in the understanding of its function and potential implications for hearing disorders. Its versatility and reliability make it a valuable asset for studies in auditory biology and related fields.
Product Name:
WHRN Rabbit Polyclonal Antibody
SKU:
CAB10773
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 708-907 of human WHRN (NP_056219.3).
This gene is thought to function in the organization and stabilization of sterocilia elongation and actin cystoskeletal assembly, based on studies of the related mouse gene. Mutations in this gene have been associated with autosomal recessive non-syndromic deafness and Usher Syndrome. Alternative splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
25861
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using WHRN Rabbit pAb (CAB10773) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
