The WFDC2 Polyclonal Antibody (CAB6788) is specifically designed for research involving WFDC2, a protein that plays a significant role in cancer development and progression. This antibody, generated in rabbits, shows high reactivity with human samples and has been validated for use in Western blot applications. By binding to the WFDC2 protein, researchers can effectively detect and analyze its expression in a variety of cell types, making it an essential tool for studies in oncology and cancer biology.
WFDC2, also known as HE4, is a biomarker that has been associated with multiple types of cancer, including ovarian, breast, and lung cancer. Its overexpression has been linked to tumor growth, metastasis, and resistance to chemotherapy, highlighting its potential as a prognostic marker and therapeutic target. By studying WFDC2 expression and function, researchers can gain valuable insights into cancer biology and potentially develop novel strategies for cancer diagnosis and treatment.
Product Name:
HE4/WFDC2 Rabbit Polyclonal Antibody
SKU:
CAB6788
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 31-124 of human HE4/WFDC2 (NP_006094.3).
This gene encodes a protein that is a member of the WFDC domain family. The WFDC domain, or WAP Signature motif, contains eight cysteines forming four disulfide bonds at the core of the protein, and functions as a protease inhibitor in many family members. This gene is expressed in pulmonary epithelial cells, and was also found to be expressed in some ovarian cancers. The encoded protein is a small secretory protein, which may be involved in sperm maturation.
Purification Method:
Affinity purification
Gene ID:
10406
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of extracts of OVCAR3 cells, using HE4/WFDC2 antibody (CAB6788) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 180s.
