The WDYHV1 Polyclonal Antibody (PACO39594) is a valuable tool for researchers studying the WDYHV1 protein, a key player in cell signaling pathways. This antibody, generated in rabbits, exhibits high reactivity with human samples and is validated for use in Western blot applications. By specifically binding to the WDYHV1 protein, this antibody enables precise detection and analysis in a variety of cell types, making it an excellent choice for studies in cell biology and signal transduction.WDYHV1 is a critical regulator of cell signaling processes, influencing cellular behavior and gene expression. Its involvement in signal transduction pathways makes it a notable target for research in various fields, including cancer biology, developmental biology, and molecular pharmacology.
Understanding the role of WDYHV1 can provide valuable insights into disease mechanisms and potential therapeutic strategies targeting aberrant signaling pathways.Overall, the WDYHV1 Polyclonal Antibody is a versatile tool for researchers interested in investigating the functions and mechanisms of the WDYHV1 protein in cellular processes. Its high specificity and sensitivity make it an essential reagent for studies aiming to unravel the complexities of signal transduction and cellular communication.
Antibody Name:
WDYHV1 Antibody (PACO39594)
Antibody SKU:
PACO39594
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
ELISA:1:2000-1:10000, WB:1:500-1:2000
Species Reactivity:
Human, Mouse
Immunogen:
Recombinant Human Protein N-terminal glutamine amidohydrolase protein (1-205AA)
Western blot. All lanes: WDYHV1 antibody at 6µg/ml. Lane 1: Mouse heart tissue. Lane 2: MCF-7 whole cell lysate. Lane 3: U251 whole cell lysate. Secondary. Goat polyclonal to rabbit IgG at 1/10000 dilution. Predicted band size: 24, 17 kDa. Observed band size: 24 kDa.
Background:
Mediates the side-chain deamidation of N-terminal glutamine residues to glutamate, an important step in N-end rule pathway of protein degradation. Conversion of the resulting N-terminal glutamine to glutamate renders the protein susceptible to arginylation, polyubiquitination and degradation as specified by the N-end rule. Does not act on substrates with internal or C-terminal glutamine and does not act on non-glutamine residues in any position. Does not deaminate acetylated N-terminal glutamine. With the exception of proline, all tested second-position residues on substrate peptides do not greatly influence the activity. In contrast, a proline at position 2, virtually abolishes deamidation of N-terminal glutamine (By similarity).
WDYHV1: Mediates the side-chain deamidation of N-terminal glutamine residues to glutamate, an important step in N-end rule pathway of protein degradation. Conversion of the resulting N- terminal glutamine to glutamate renders the protein susceptible to arginylation, polyubiquitination and degradation as specified by the N-end rule. Does not act on substrates with internal or C- terminal glutamine and does not act on non-glutamine residues in any position. Does not deaminate acetylated N-terminal glutamine. With the exception of proline, all tested second-position residues on substrate peptides do not greatly influence the activity. In contrast, a proline at position 2, virtually abolishes deamidation of N-terminal glutamine. Belongs to the NTAQ1 family.Protein type: EC 3.5.1.-Chromosomal Location of Human Ortholog: 8q24.13Cellular Component: cytosol; nucleusMolecular Function: protein bindingBiological Process: protein modification process
