The WDR74 Polyclonal Antibody (PAC036846) is a valuable tool for researchers studying the WDR74 protein, which is involved in various cellular processes such as cell cycle regulation and chromatin organization. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By specifically binding to the WDR74 protein, this antibody allows for precise detection and analysis in a wide range of cell types, making it well-suited for studies in molecular biology and cancer research.WDR74, a member of the WD repeat protein family, plays a critical role in maintaining genomic stability and regulating gene expression.
Dysregulation of WDR74 has been associated with various diseases, including cancer and developmental disorders. By elucidating the functions of WDR74, researchers can gain insights into the underlying mechanisms of these conditions and potentially identify novel therapeutic targets.Overall, the WDR74 Polyclonal Antibody is an essential tool for investigating the role of WDR74 in cellular processes and disease development. Its high specificity and sensitivity make it a reliable choice for researchers seeking to unravel the complex functions of this important protein.
Western blot. All lanes: WDR74 antibody at 0.5µg/ml + Hela whole cell lysate. Secondary. Goat polyclonal to rabbit IgG at 1/10000 dilution. Predicted band size: 43, 41 kDa. Observed band size: 43 kDa.
Immunohistochemistry of paraffin-embedded human liver tissue using PACO36846 at dilution of 1:100.
Immunohistochemistry of paraffin-embedded human pancreatic tissue using PACO36846 at dilution of 1:100.
Background:
Regulatory protein of the MTREX-exosome complex involved in the synthesis of the 60S ribosomal subunit. Participates in an early cleavage of the pre-rRNA processing pathway in cooperation with NVL. Required for blastocyst formation, is necessary for RNA transcription, processing and/or stability during preimplantation development (By similarity).
Synonyms:
WD repeat-containing protein 74 (NOP seven-associated protein 1), WDR74, NSA1
UniProt Protein Function:
WDR74: 2 isoforms of the human protein are produced by alternative splicing.Protein type: Nucleolus; Unknown functionChromosomal Location of Human Ortholog: 11q12.3Cellular Component: nucleolus; nucleusBiological Process: RNA metabolic process; blastocyst formation
