The WDR60 Polyclonal Antibody (PAC046926) is a valuable research tool for studying WDR60, a protein involved in cellular processes such as DNA repair and cell cycle regulation. This antibody, produced in rabbits, exhibits high reactivity with human samples and is validated for use in Western blotting applications. By binding to the WDR60 protein, this antibody enables accurate detection and analysis in a variety of cell types, making it an excellent choice for research in molecular biology and cancer studies.
WDR60 is known for its role in maintaining genomic stability and regulating cell division, making it a crucial target for investigating diseases related to DNA damage and abnormal cell growth. Understanding the function of WDR60 can provide insights into the development of new therapies for cancer and other disorders characterized by defective DNA repair mechanisms. The WDR60 Polyclonal Antibody is an essential tool for researchers interested in exploring the molecular mechanisms underlying these conditions.
Immunohistochemistry of paraffin-embedded human brain tissue using PACO46926 at dilution of 1:100.
Immunofluorescent analysis of HepG2 cells using PACO46926 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
Background:
May play a role in ciliogenesis.
Synonyms:
WD repeat-containing protein 60, WDR60
UniProt Protein Function:
May play a role in ciliogenesis.
UniProt Protein Details:
NCBI Summary:
This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD) and may facilitate the formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes including cell cycle progression, signal transduction, apoptosis, and gene regulation. The encoded protein contains four WD repeats and may play a role in the formation of cilia. Mutations in this gene have been associated with short-rib polydactyly and Jeune syndromes. [provided by RefSeq, Mar 2014]
