The WDR48 Polyclonal Antibody (CAB6854) is a valuable tool for researchers studying the WD repeat-containing protein 48 (WDR48), a key player in various cellular processes, including DNA damage repair and protein degradation. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blotting applications. By specifically targeting the WDR48 protein, this antibody facilitates the detection and analysis of WDR48 in different cell types, making it an essential component of studies in molecular biology and cancer research.WDR48 is known to interact with multiple proteins involved in DNA repair pathways, making it a crucial component in maintaining genomic stability and preventing the formation of cancerous cells.
Additionally, WDR48 has been implicated in regulating protein turnover and degradation, suggesting its involvement in cellular homeostasis. Research into the functions of WDR48 is vital for unraveling its role in diseases such as cancer and neurodegenerative disorders, ultimately paving the way for the development of targeted therapies aimed at manipulating WDR48 activity for therapeutic benefits.
Product Name:
WDR48 Rabbit Polyclonal Antibody
SKU:
CAB6854
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 450-677 of human WDR48 (NP_065890.1).
The protein encoded by this gene has been shown to interact with ubiquitin specific peptidase 1 (USP1), activating the deubiquitinating activity of USP1 and allowing it to remove the ubiquitin moiety from monoubiquitinated FANCD2. FANCD2 is ubiquitinated in response to DNA damage.
Purification Method:
Affinity purification
Gene ID:
57599
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using WDR48 Rabbit pAb (CAB6854) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 15s.
