The WDR45 Polyclonal Antibody (CAB7581) is a valuable tool for research involving WDR45, a protein involved in autophagy and neurodevelopmental disorders. This antibody, produced in rabbits, is highly specific to human samples and has been validated for use in Western blot applications. By binding to the WDR45 protein, this antibody allows for the detection and analysis of WDR45 in various cell types, making it ideal for studies in neurobiology and related fields.WDR45, also known as WIPI4, plays a crucial role in the autophagy pathway by regulating the formation of autophagosomes. Mutations in the WDR45 gene have been associated with neurodegenerative disorders such as beta-propeller protein-associated neurodegeneration (BPAN).
Understanding the function of WDR45 is essential for unraveling the mechanisms underlying these devastating conditions and developing potential therapeutic interventions.Overall, the WDR45 Polyclonal Antibody (CAB7581) serves as a powerful tool for researchers investigating the role of WDR45 in autophagy and neurodevelopmental disorders. Its high specificity and sensitivity make it an indispensable reagent for studies aiming to elucidate the biological functions of WDR45 and its potential implications in disease pathogenesis.
Product Name:
WDR45 Rabbit Polyclonal Antibody
SKU:
CAB7581
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 35-148 of human WDR45 (NP_001025067.1).
This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This gene has a pseudogene at chromosome 4q31.3. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene, but the biological validity and full-length nature of some variants have not been determined.
Purification Method:
Affinity purification
Gene ID:
11152
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using WDR45 antibody (CAB7581) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 60s.
