The WDR41 Polyclonal Antibody (PAC063875) is a valuable tool for researchers studying WDR41, a protein involved in various cellular processes such as DNA repair and regulation of gene expression. This antibody, raised in rabbits, has high specificity for WDR41 in human samples and is validated for use in Western blot applications. By binding to the WDR41 protein, the antibody allows for precise detection and analysis in different cell types, making it suitable for research in molecular biology and cancer biology.
WDR41 is known to interact with key proteins involved in DNA repair pathways, suggesting its potential role in maintaining genomic stability and preventing mutations. Research on WDR41 is important for understanding its function in cellular processes and its potential implications in diseases such as cancer. The WDR41 Polyclonal Antibody provides researchers with a reliable tool to investigate the role of WDR41 in various biological processes, leading to potential insights for therapeutic interventions.
Antibody Name:
WDR41 Antibody (PACO63875)
Antibody SKU:
PACO63875
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IF
Recommended Dilutions:
ELISA:1:2000-1:10000, IF:1:50-1:200
Species Reactivity:
Human
Immunogen:
Recombinant Human WD repeat-containing protein 41 protein (7-284AA)
Immunofluorescence staining of U251 cells with PACO63875 at 1:166, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
Background:
Non-catalytic component of the C9orf72-SMCR8 complex, a complex that has guanine nucleotide exchange factor (GEF) activity and regulates autophagy. The C9orf72-SMCR8 complex promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB8A and RAB39B into their active GTP-bound form, thereby promoting autophagosome maturation. The C9orf72-SMCR8 complex also acts as a negative regulator of autophagy initiation by interacting with the ATG1/ULK1 kinase complex and inhibiting its protein kinase activity.
Synonyms:
WD repeat-containing protein 41, WDR41
UniProt Protein Function:
WDR41: 2 isoforms of the human protein are produced by alternative splicingChromosomal Location of Human Ortholog: 5q13.3Cellular Component: lysosomal membrane
