The WDR36 Polyclonal Antibody (PAC020877) is a vital tool for researchers studying WDR36, a protein associated with glaucoma and other eye-related conditions. This antibody, produced in rabbits, exhibits high specificity and sensitivity in detecting WDR36 in human samples, making it suitable for use in various research applications such as Western blotting.WDR36, also known as WD repeat-containing protein 36, is involved in the regulation of intraocular pressure and the maintenance of optic nerve function. Mutations in the WDR36 gene have been linked to primary open-angle glaucoma, a leading cause of irreversible blindness worldwide.
By understanding the function and regulation of WDR36, researchers can gain valuable insights into the mechanisms underlying glaucoma development and potentially identify new therapeutic targets for treatment.With its ability to specifically target WDR36, the PAC020877 antibody is a valuable tool for researchers investigating the role of WDR36 in eye health and disease. Its high reactivity and reliability make it an essential component for studies aiming to advance our understanding of glaucoma and other eye disorders.
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO20877(WDR36 Antibody) at dilution 1/35, on the right is treated with synthetic peptide. (Original magnification: x200).
Gel: 6%SDS-PAGE,Lysate: 40 μgPrimary antibody: PACO20877(WDR36 Antibody) at dilution 1/200 dilution,Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution,Exposure time: 1 minute.
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO20877(WDR36 Antibody) at dilution 1/35, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acid, typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. Mutations in this gene have been associated with adult-onset primary open-angle glaucoma (POAG).
Synonyms:
WD repeat domain 36
UniProt Protein Function:
WDR36: Involved in T-cell activation and highly co-regulated with IL2. Defects in WDR36 are the cause of primary open angle glaucoma type 1G (GLC1G). Primary open angle glaucoma (POAG) is characterized by a specific pattern of optic nerve and visual field defects. The angle of the anterior chamber of the eye is open, and usually the intraocular pressure is increased. The disease is asymptomatic until the late stages, by which time significant and irreversible optic nerve damage has already taken place.
UniProt Protein Details:
Protein type:Nucleolus
Chromosomal Location of Human Ortholog: 5q22.1
Cellular Component: small subunit processome; nucleolus
Biological Process: retinal homeostasis; visual perception; response to stimulus; regulation of axon extension; rRNA processing
Disease: Glaucoma 1, Open Angle, G
NCBI Summary:
This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. Mutations in this gene have been associated with adult-onset primary open-angle glaucoma (POAG). [provided by RefSeq, Jul 2008]
