| UniProt Protein Function: | WDR34: Acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways. Inhibits the MAP3K7-induced NF-kappa- B activation pathway. Inhibits MAP3K7 phosphorylation at 'Thr-184' and 'Thr-187' upon Il-1 beta stimulation.Chromosomal Location of Human Ortholog: 9q34.11Cellular Component: axoneme; centriole; cytoplasmMolecular Function: protein bindingDisease: Short-rib Thoracic Dysplasia 11 With Or Without Polydactyly |
| UniProt Protein Details: | |
| NCBI Summary: | This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. Defects in this gene are a cause of short-rib thoracic dysplasia 11 with or without polydactyly. [provided by RefSeq, Mar 2014] |
| UniProt Code: | Q96EX3 |
| NCBI GenInfo Identifier: | 88985038 |
| NCBI Gene ID: | 89891 |
| NCBI Accession: | Q96EX3.2 |
| UniProt Secondary Accession: | Q96EX3,Q5VXV4, Q9BV46 |
| UniProt Related Accession: | Q96EX3 |
| Molecular Weight: | 57,801 Da |
| NCBI Full Name: | WD repeat-containing protein 34 |
| NCBI Synonym Full Names: | WD repeat domain 34 |
| NCBI Official Symbol: | WDR34Â Â |
| NCBI Official Synonym Symbols: | DIC5; FAP133; SRTD11; bA216B9.3Â Â |
| NCBI Protein Information: | WD repeat-containing protein 34 |
| UniProt Protein Name: | WD repeat-containing protein 34 |
| UniProt Synonym Protein Names: | |
| Protein Family: | WD repeat-containing protein |
| UniProt Gene Name: | WDR34Â Â |
| UniProt Entry Name: | WDR34_HUMAN |
