The WDR34 Polyclonal Antibody (PAC038970) is a valuable tool for researchers studying WDR34, a protein involved in various cellular processes including ciliogenesis and ciliary function. This antibody, raised in rabbits, exhibits high specificity and sensitivity towards human samples, making it suitable for Western blot applications. By binding to the WDR34 protein, this antibody allows for the detection and analysis of WDR34 in different cell types, making it an ideal choice for studies in cell biology and developmental biology.WDR34 is known to play a crucial role in the formation and function of cilia, hair-like structures on the surface of cells that are involved in various physiological processes such as cell signaling and development.
Dysregulation of ciliary function has been linked to a range of diseases including ciliopathies and cancer. Research on WDR34 can provide insights into the mechanisms underlying these conditions and may lead to the development of targeted therapies. The WDR34 Polyclonal Antibody is a valuable tool for investigating the function of WDR34 and its role in health and disease.
Western blot. All lanes: WDR34 antibody at 1.5µg/ml. Lane 1: PC-3 whole cell lysate. Lane 2: MDA-MB-231 whole cell lysate. Secondary. Goat polyclonal to rabbit IgG at 1/10000 dilution. Predicted band size: 58 kDa. Observed band size: 58 kDa.
Immunohistochemistry of paraffin-embedded human gastric cancer using PACO38970 at dilution of 1:100.
Background:
Critical for ciliary functions, essential to normal development and survival, most probably as a previously unrecognized component of the mammalian dynein-motor-based intraflagellar transport (IFT) machinery. Acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways. Inhibits the MAP3K7-induced NF-kappa-B activation pathway. Inhibits MAP3K7 phosphorylation at 'Thr-184' and 'Thr-187' upon Il-1 β stimulation.
Synonyms:
WD repeat-containing protein 34, WDR34
UniProt Protein Function:
WDR34: Acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways. Inhibits the MAP3K7-induced NF-kappa- B activation pathway. Inhibits MAP3K7 phosphorylation at 'Thr-184' and 'Thr-187' upon Il-1 beta stimulation.Chromosomal Location of Human Ortholog: 9q34.11Cellular Component: axoneme; centriole; cytoplasmMolecular Function: protein bindingDisease: Short-rib Thoracic Dysplasia 11 With Or Without Polydactyly
UniProt Protein Details:
NCBI Summary:
This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. Defects in this gene are a cause of short-rib thoracic dysplasia 11 with or without polydactyly. [provided by RefSeq, Mar 2014]
