The WDR18 Polyclonal Antibody (CAB15875) is a valuable tool for researchers studying the WDR18 protein, a component of the spliceosome complex involved in pre-mRNA splicing. This antibody, generated in rabbits, exhibits high specificity and sensitivity towards WDR18 in human samples, making it suitable for use in Western blot applications. By binding to the WDR18 protein, this antibody enables precise detection and analysis in various cell types, facilitating investigations in molecular biology and gene expression studies.
WDR18 plays a crucial role in RNA processing by participating in the splicing of precursor mRNA molecules, impacting gene regulation and protein synthesis. Dysregulation of WDR18 expression has been linked to diseases such as cancer and neurodevelopmental disorders, highlighting its potential as a therapeutic target for drug development and precision medicine. By elucidating the function of WDR18, researchers can gain insights into the mechanisms underlying these conditions and pave the way for novel treatment strategies.
Product Name:
WDR18 Rabbit Polyclonal Antibody
SKU:
CAB15875
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 243-432 of human WDR18 (NP_077005.2).
This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation.
Purification Method:
Affinity purification
Gene ID:
57418
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using WDR18 Rabbit pAb (CAB15875) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 120s.
