The WDR12 Polyclonal Antibody (CAB15477) is a valuable tool for researchers studying the WDR12 protein, a component of the Paf1 complex involved in RNA polymerase II transcription. This antibody, raised in rabbits, offers high reactivity with human samples and is validated for Western blot applications. By binding to the WDR12 protein, this antibody enables detection and analysis in various cell types, making it an ideal choice for studies in molecular biology and gene regulation.WDR12 plays a crucial role in transcriptional regulation, making it a key player in gene expression and cellular processes.
Its involvement in the Paf1 complex highlights its importance in controlling RNA polymerase II activity and ultimately gene transcription. Research into the function of WDR12 can provide valuable insights into mechanisms underlying gene regulation, with implications for understanding diseases such as cancer and developmental disorders. The WDR12 Polyclonal Antibody is a reliable tool for investigating the role of WDR12 in these contexts and advancing our knowledge of transcriptional control.
Product Name:
WDR12 Rabbit Polyclonal Antibody
SKU:
CAB15477
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-280 of human WDR12 (NP_060726.3).
This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This protein is highly similar to the mouse WD repeat domain 12 protein at the amino acid level. The protein encoded by this gene is a component of a nucleolar protein complex that affects maturation of the large ribosomal subunit.
Purification Method:
Affinity purification
Gene ID:
55759
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using WDR12 Rabbit pAb (CAB15477) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
