The WDPCP Polyclonal Antibody (PAC037586) is a valuable tool for researchers studying WDPCP, a protein involved in various cellular processes. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By specifically binding to the WDPCP protein, this antibody enables accurate detection and analysis in a variety of cell types, making it an essential component for studies in developmental biology, cilia formation, and ciliopathies.WDPCP, also known as WD repeat-containing and planar cell polarity effector, plays a crucial role in regulating cell polarity and tissue development.
Dysregulation of WDPCP has been linked to various genetic disorders and developmental abnormalities, highlighting its importance in biological processes. By investigating the function of WDPCP, researchers can gain insights into fundamental biological mechanisms and potentially uncover novel therapeutic targets for a range of conditions. Overall, the WDPCP Polyclonal Antibody is a reliable tool for researchers seeking to further understand the role of WDPCP in cellular processes, offering valuable insights that could impact future research and therapeutic development in the field of developmental biology and related disciplines.
Antibody Name:
Wdpcp Antibody (PACO37586)
Antibody SKU:
PACO37586
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
ELISA:1:2000-1:10000, WB:1:1000-1:5000
Species Reactivity:
Mouse
Immunogen:
Recombinant Mouse WD repeat-containing and planar cell polarity effector protein fritz homolog protein (1-722AA)
Western blot. All lanes: Wdpcp antibody at 2µg/ml + Mouse brain tissue. Secondary. Goat polyclonal to rabbit IgG at 1/10000 dilution. Predicted band size: 82, 73 kDa. Observed band size: 82 kDa.
Background:
Probable effector of the planar cell polarity signaling pathway which regulates the septin cytoskeleton in both ciliogenesis and collective cell movements By similarity.
Synonyms:
WD repeat-containing and planar cell polarity effector protein fritz homolog (mFrtz) (Homolog-13) (WD repeat-containing and planar cell polarity effector protein), Wdpcp
UniProt Protein Function:
LOC51057: Probable effector of the planar cell polarity signaling pathway which regulates the septin cytoskeleton in both ciliogenesis and collective cell movements. Defects in WDPCP are the cause of Bardet-Biedl syndrome type 15 (BBS15). Bardet-Biedl syndrome (BBS) is a genetically heterogeneous, autosomal recessive disorder characterized by usually severe pigmentary retinopathy, early onset obesity, polydactyly, hypogenitalism, renal malformation and mental retardation. Secondary features include diabetes mellitus, hypertension and congenital heart disease. Bardet-Biedl syndrome inheritance is autosomal recessive, but three mutated alleles (two at one locus, and a third at a second locus) may be required for clinical manifestation of some forms of the disease. Mutations in WDPCP may act as modifiers of the phenotypic expression of Bardet-Biedl syndrome and Meckel syndrome by interacting in trans with primary BBS and MKS loci. Belongs to the WD repeat fritz family. 3 isoforms of the human protein are produced by alternative splicing.Cellular Component: cell projection; cilium; cytoplasm; cytoskeleton; membrane; plasma membraneMolecular Function: protein bindingBiological Process: auditory receptor cell morphogenesis; camera-type eye development; cell projection organization and biogenesis; cilium biogenesis; embryonic digit morphogenesis; embryonic organ development; establishment of protein localization; kidney development; nervous system development; palate development; regulation of focal adhesion formation; smoothened signaling pathway
