UniProt Protein Function: | WDFY1: Binds PtdIns3P in vitro with high specificity over other phosphoinositides.Chromosomal Location of Human Ortholog: 2q36.1Cellular Component: cytosol; early endosome; nucleusMolecular Function: phosphatidylinositol binding; protein bindingBiological Process: positive regulation of toll-like receptor 3 signaling pathway; positive regulation of toll-like receptor 4 signaling pathway |
UniProt Protein Details: | |
NCBI Summary: | The protein encoded by this gene is a phosphatidylinositol 3-phosphate binding protein, which contains a FYVE zinc finger domain and multiple WD-40 repeat domains. When exogenously expressed, it localizes to early endosomes. Mutagenesis analysis demonstrates that this endosomal localization is mediated by the FYVE domain. [provided by RefSeq, Jan 2015] |
UniProt Code: | Q8IWB7 |
NCBI GenInfo Identifier: | 18482373 |
NCBI Gene ID: | 57590 |
NCBI Accession: | NP_065881.1 |
UniProt Secondary Accession: | Q8IWB7,Q53S17, Q9H9D5, Q9P2B3 |
UniProt Related Accession: | Q8IWB7 |
Molecular Weight: | |
NCBI Full Name: | WD repeat and FYVE domain-containing protein 1 |
NCBI Synonym Full Names: | WD repeat and FYVE domain containing 1 |
NCBI Official Symbol: | WDFY1Â Â |
NCBI Official Synonym Symbols: | WDF1; FENS-1; ZFYVE17Â Â |
NCBI Protein Information: | WD repeat and FYVE domain-containing protein 1 |
UniProt Protein Name: | WD repeat and FYVE domain-containing protein 1 |
UniProt Synonym Protein Names: | FENS-1; Phosphoinositide-binding protein 1; WD40- and FYVE domain-containing protein 1; Zinc finger FYVE domain-containing protein 17 |
Protein Family: | WD repeat and FYVE domain-containing protein |
UniProt Gene Name: | WDFY1Â Â |
UniProt Entry Name: | WDFY1_HUMAN |