The WASL Polyclonal Antibody (CAB2576) is specially designed for research involving WASL, a key protein involved in actin cytoskeleton dynamics and cell motility. This antibody, developed in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By binding to the WASL protein, this antibody enables researchers to detect and analyze WASL expression in various cell types, making it an excellent tool for studies in cell biology and cancer research.
WASL, also known as Wiskott-Aldrich syndrome protein, plays a crucial role in regulating actin polymerization and cell migration processes. Dysregulation of WASL has been implicated in various diseases, including cancer and autoimmune disorders, making it a promising target for therapeutic interventions. Studying the functions of WASL is essential for gaining insights into its contribution to disease pathogenesis and developing novel treatment strategies targeting actin cytoskeleton dynamics.
Product Name:
N-WASP/WASL Rabbit Polyclonal Antibody
SKU:
CAB2576
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-250 of human N-WASP/WASL (NP_003932.3).
This gene encodes a member of the Wiskott-Aldrich syndrome (WAS) protein family. Wiskott-Aldrich syndrome proteins share similar domain structure, and associate with a variety of signaling molecules to alter the actin cytoskeleton. The encoded protein is highly expressed in neural tissues, and interacts with several proteins involved in cytoskeletal organization, including cell division control protein 42 (CDC42) and the actin-related protein-2/3 (ARP2/3) complex. The encoded protein may be involved in the formation of long actin microspikes, and in neurite extension.
Purification Method:
Affinity purification
Gene ID:
8976
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of lysates from Rat kidney using N-WASP/WASL Rabbit pAb(CAB2576) at 1:2000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25 μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
