The WashC3 Polyclonal Antibody (PAC042622) is a valuable tool for researchers studying WashC3, a protein involved in cellular processes related to endocytosis and intracellular trafficking. This antibody, generated in rabbits, has high specificity for WashC3 in human samples and is optimized for Western blot applications. By targeting WashC3, researchers can observe and analyze its expression and function in various cell types, making it an essential tool for studies in cell biology and molecular biology.
WashC3 plays a key role in maintaining cellular homeostasis by regulating the recycling of cell surface receptors and vesicle trafficking. Its involvement in endocytic pathways makes it a potential target for investigating diseases related to impaired vesicle trafficking, such as neurodegenerative disorders and metabolic diseases. Understanding the function of WashC3 is essential for developing therapies that target aberrant vesicle trafficking mechanisms implicated in these conditions.
Antibody Name:
WASHC3 Antibody (PACO42622)
Antibody SKU:
PACO42622
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA
Recommended Dilutions:
Species Reactivity:
Human
Immunogen:
Recombinant Human WASH complex subunit 3 protein (1-194AA)
Acts at least in part as component of the WASH core complex whose assembly at the surface of endosomes seems to inhibit WASH nucleation-promoting factor (NPF) activity in recruiting and activating the Arp2/3 complex to induce actin polymerization, and which is involved in regulation of the fission of tubules that serve as transport intermediates during endosome sorting.
Synonyms:
WASH complex subunit 3 (Coiled-coil domain-containing protein 53), WASHC3
UniProt Protein Function:
CCDC53: Component of the WASH complex, a complex present at the surface of endosomes that recruits and activates the Arp2/3 complex to induce actin polymerization. The WASH complex plays a key role in the fission of tubules that serve as transport intermediates during endosome sorting. Belongs to the CCDC53 family.Chromosomal Location of Human Ortholog: 12q23.2Cellular Component: intracellular membrane-bound organelle; early endosome; actin cytoskeletonMolecular Function: protein bindingBiological Process: protein transport
