WASF3 Antibody (PACO20871)
- SKU:
- PACO20871
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
WASF3 Antibody (PACO20871)
The WASF3 Polyclonal Antibody (PAC020871) is a valuable tool for researchers studying Wiskott-Aldrich Syndrome protein family member 3 (WASF3), a key regulator of cytoskeletal dynamics and cell migration. This antibody, generated in rabbits, exhibits high specificity and sensitivity for detecting WASF3 expression in human samples, making it suitable for various research applications such as Western blot analysis.WASF3 is known to play a critical role in promoting cell migration and invasion, making it a potential target for therapeutic interventions in cancer metastasis.
By targeting WASF3, researchers hope to inhibit the aggressive behavior of cancer cells and potentially improve patient outcomes in various types of cancer. The WASF3 Polyclonal Antibody enables researchers to investigate the role of WASF3 in cancer progression and metastasis, offering valuable insights into potential therapeutic strategies for combating cancer.
| Antibody Name: | WASF3 Antibody (PACO20871) |
| Antibody SKU: | PACO20871 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:5000, IHC:1:20-1:100 |
| Species Reactivity: | Human, Mouse |
| Immunogen: | Synthetic peptide of human WASF3 |
| Form: | Liquid |
| Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| Purification Method: | Antigen affinity purification |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using PACO20871(WASF3 Antibody) at dilution 1/25, on the right is treated with synthetic peptide. (Original magnification: x200). |
| Background: | This gene encodes a member of the Wiskott-Aldrich syndrome protein family. The gene product is a protein that forms a multiprotein complex that links receptor kinases and actin. Binding to actin occurs through a C-terminal verprolin homology domain in all family members. The multiprotein complex serves to tranduce signals that involve changes in cell shape, motility or function. A pseudogene of this gene have been defined on chromosome 6. Alternative splicing results in multiple transcript variants |
| Synonyms: | WAS protein family, member 3 |
| UniProt Protein Function: | WASF3: Downstream effector molecules involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape. Binds actin and the Arp2/3 complex. Expressed in ovary and brain. Belongs to the SCAR/WAVE family. |
| UniProt Protein Details: | Protein type:Actin-binding; Motility/polarity/chemotaxis Chromosomal Location of Human Ortholog: 13q12 Cellular Component: cytoskeleton; lamellipodium; cytoplasm Molecular Function:actin binding Biological Process: positive regulation of myelination; lamellipodium biogenesis; regulation of cell shape; actin filament polymerization; cytoskeleton organization and biogenesis; protein complex assembly; oligodendrocyte development |
| NCBI Summary: | This gene encodes a member of the Wiskott-Aldrich syndrome protein family. The gene product is a protein that forms a multiprotein complex that links receptor kinases and actin. Binding to actin occurs through a C-terminal verprolin homology domain in all family members. The multiprotein complex serves to tranduce signals that involve changes in cell shape, motility or function. A pseudogene of this gene have been defined on chromosome 6. Alternative splicing results in multiple transcript variants [provided by RefSeq, May 2014] |
| UniProt Code: | Q9UPY6 |
| NCBI GenInfo Identifier: | 13699803 |
| NCBI Gene ID: | 10810 |
| NCBI Accession: | NP_006637.2 |
| UniProt Secondary Accession: | Q9UPY6,O94974, Q86VQ2, |
| UniProt Related Accession: | Q9UPY6 |
| Molecular Weight: | 55,293 Da |
| NCBI Full Name: | wiskott-Aldrich syndrome protein family member 3 isoform 1 |
| NCBI Synonym Full Names: | WAS protein family, member 3 |
| NCBI Official Symbol: | WASF3Â Â |
| NCBI Official Synonym Symbols: | SCAR3; WAVE3; Brush-1Â Â |
| NCBI Protein Information: | wiskott-Aldrich syndrome protein family member 3; protein WAVE-3; WASP family Verprolin-homologous protein 3; verprolin homology domain-containing protein 3 |
| UniProt Protein Name: | Wiskott-Aldrich syndrome protein family member 3 |
| UniProt Synonym Protein Names: | Protein WAVE-3; Verprolin homology domain-containing protein 3 |
| Protein Family: | Wiskott-Aldrich syndrome protein family |
| UniProt Gene Name: | WASF3Â Â |
| UniProt Entry Name: | WASF3_HUMAN |
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