The WAS Polyclonal Antibody (CAB0978) is a valuable tool for researchers studying the Wiskott-Aldrich Syndrome protein (WAS), a key regulator of actin polymerization and cytoskeletal organization. This antibody, generated in rabbits, demonstrates high specificity and sensitivity for detecting WAS protein in human samples, making it an excellent choice for Western blot applications.WAS is a critical player in immune cell function and signaling, with mutations in the gene leading to the development of Wiskott-Aldrich Syndrome, a primary immunodeficiency disorder. By targeting the WAS protein, researchers can investigate its role in immune cell development, activation, and immune responses, providing insights into the pathogenesis of Wiskott-Aldrich Syndrome and other related disorders.
With its ability to detect and study the expression of WAS protein in various cell types, the WAS Polyclonal Antibody (CAB0978) is an essential tool for immunology, hematology, and immunodeficiency research. By understanding the function of WAS at the molecular level, researchers can pave the way for the development of targeted therapies for patients with Wiskott-Aldrich Syndrome and other immune disorders.
Product Name:
WASP Rabbit Polyclonal Antibody
SKU:
CAB0978
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 60-250 of human WASPP (NP_000368.1).
The Wiskott-Aldrich syndrome (WAS) family of proteins share similar domain structure, and are involved in transduction of signals from receptors on the cell surface to the actin cytoskeleton. The presence of a number of different motifs suggests that they are regulated by a number of different stimuli, and interact with multiple proteins. Recent studies have demonstrated that these proteins, directly or indirectly, associate with the small GTPase, Cdc42, known to regulate formation of actin filaments, and the cytoskeletal organizing complex, Arp2/3. Wiskott-Aldrich syndrome is a rare, inherited, X-linked, recessive disease characterized by immune dysregulation and microthrombocytopenia, and is caused by mutations in the WAS gene. The WAS gene product is a cytoplasmic protein, expressed exclusively in hematopoietic cells, which show signalling and cytoskeletal abnormalities in WAS patients. A transcript variant arising as a result of alternative promoter usage, and containing a different 5' UTR sequence, has been described, however, its full-length nature is not known.
Purification Method:
Affinity purification
Gene ID:
7454
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using WASPP Antibody (CAB0978) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).
