The VWF Polyclonal Antibody (CAB1335) is a valuable tool for researchers studying von Willebrand factor (VWF), a key protein involved in blood clotting and platelet function. This antibody, produced in rabbits, is specifically designed to target VWF in human samples, making it an essential reagent for studies involving VWF expression and regulation.VWF is integral to hemostasis, playing a crucial role in the formation of blood clots and wound healing. Dysregulation of VWF can lead to bleeding disorders such as von Willebrand disease and thrombotic conditions like thrombotic thrombocytopenic purpura.
By using the VWF Polyclonal Antibody, researchers can detect and analyze VWF levels in various cell types and tissues, aiding in the investigation of VWF-related diseases and potential therapeutic interventions.Furthermore, the VWF Polyclonal Antibody is validated for use in Western blot applications, ensuring reliable and accurate results for researchers studying VWF function and dysfunction. Its high reactivity and specificity make it an essential tool for advancing knowledge in the fields of hematology, cardiovascular research, and vascular biology.
Product Name:
VWF Rabbit Polyclonal Antibody
SKU:
CAB1335
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 2645-2813 of human von Willebrand factor (VWF) (NP_000543.2).
This gene encodes a glycoprotein involved in hemostasis. The encoded preproprotein is proteolytically processed following assembly into large multimeric complexes. These complexes function in the adhesion of platelets to sites of vascular injury and the transport of various proteins in the blood. Mutations in this gene result in von Willebrand disease, an inherited bleeding disorder. An unprocessed pseudogene has been found on chromosome 22.
Purification Method:
Affinity purification
Gene ID:
7450
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of lysates from ECV-304 cells, using von Willebrand factor (VWF) Rabbit pAb (CAB1335) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 180s.
