The VWA5A Polyclonal Antibody (PAC015859) is a valuable tool for researchers studying the protein VWA5A, which plays a key role in various cellular processes. This antibody, generated in rabbits, exhibits high reactivity towards human samples and has been validated for use in Western blotting applications. By binding specifically to the VWA5A protein, this antibody enables accurate detection and analysis in a variety of cell types, making it a versatile option for studies in molecular biology and cell signaling.VWA5A is known to be involved in important biological functions such as cell adhesion, migration, and signal transduction, making it a promising target for research into diseases related to these processes.
By investigating the role of VWA5A in various cellular pathways, researchers may gain valuable insights into the development and progression of conditions such as cancer, cardiovascular diseases, and neurological disorders. The VWA5A Polyclonal Antibody offers a reliable tool for advancing our understanding of VWA5A's biological functions and its potential implications in disease mechanisms.
Antibody Name:
VWA5A Antibody (PACO15859)
Antibody SKU:
PACO15859
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:10000, IHC:1:100-1:300
Species Reactivity:
Human
Immunogen:
Fusion protein of human VWA5A
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human lung cancer tissue using PACO15859(VWA5A Antibody) at dilution 1/80, on the right is treated with fusion protein. (Original magnification: x200).
The image on the left is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using PACO15859(VWA5A Antibody) at dilution 1/80, on the right is treated with fusion protein. (Original magnification: x200).
Background:
VWA5A (von Willebrand factor A domain containing 5A), also known as BCSC-1 (breast cancer suppressor candidate 1) or LOH11CR2A (loss of heterozygosity 11 chromosomal region 2 gene A protein), is a 786 amino acid, protein containing one VIT domain and one VWFA domain. VWA5A is expressed at low levels in various tissues, with no expression found in 80% of tumor cell lines. Likely acting as a tumor suppressor gene, deletion of VWA5A leads to loss of heterozygosity (LOH) in breast and ovarian tumors, and may have an important role as a potential gene therapy target. Abnormal expression of VWA5A may lead to an increase in adhesion of CNE-2L2 cells associated with an increase in expression of E-cadherin, alpha-catenin, and p53, resulting in a decrease of malignant activity in cells with ectopic expression of VWA5A.
Synonyms:
von Willebrand factor A domain containing 5A
UniProt Protein Function:
VWA5A: May play a role in tumorigenesis as a tumor suppressor. Altered expression of this protein and disruption of the molecular pathway it is involved in, may contribute directly to or modify tumorigenesis. 4 isoforms of the human protein are produced by alternative splicing.
von Willebrand factor A domain-containing protein 5A
NCBI Synonym Full Names:
von Willebrand factor A domain containing 5A
NCBI Official Symbol:
VWA5AÂ Â
NCBI Official Synonym Symbols:
BCSC1; BCSC-1; LOH11CR2AÂ Â
NCBI Protein Information:
von Willebrand factor A domain-containing protein 5A; breast cancer suppressor candidate 1; loss of heterozygosity 11 chromosomal region 2 gene A protein; loss of heterozygosity, 11, chromosomal region 2, gene A; ortholog of mouse AW551984
UniProt Protein Name:
von Willebrand factor A domain-containing protein 5A
UniProt Synonym Protein Names:
Breast cancer suppressor candidate 1; BCSC-1; Loss of heterozygosity 11 chromosomal region 2 gene A protein
