The VTI1A Polyclonal Antibody (CAB5162) is a high-quality research tool designed for investigating VTI1A, a protein involved in intracellular membrane trafficking and vesicle fusion processes. This antibody, produced in rabbits, specifically targets the VTI1A protein and is validated for use in Western blot applications. It offers high sensitivity and specificity, making it a reliable tool for studying VTI1A expression and localization in various cell types.VTI1A plays a crucial role in regulating vesicle fusion events within cells, contributing to processes such as protein transport and secretion. Dysregulation of VTI1A function has been implicated in various diseases, including neurodegenerative disorders and metabolic syndromes.
By using the VTI1A Polyclonal Antibody, researchers can gain valuable insights into the molecular mechanisms underlying these conditions and potentially identify novel therapeutic targets.With its versatility and reliability, the VTI1A Polyclonal Antibody is an indispensable tool for studies in cell biology, neuroscience, and molecular medicine. Its ability to detect VTI1A in different experimental settings makes it an essential component of any research project aiming to elucidate the roles of VTI1A in cellular physiology and disease pathology.
Product Name:
VTI1A Rabbit Polyclonal Antibody
SKU:
CAB5162
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-180 of human VTI1A (NP_660207.2).
Cytoplasmic vesicle, Golgi apparatus membrane, Single-pass type IV membrane protein.
Calculated MW:
25kDa
Observed MW:
30kDa
The protein encoded by this gene is a member of the family of soluble N-ethylmaleimide-sensitive fusion protein-attachment protein receptors (SNAREs) that function in intracellular trafficking. This family member is involved in vesicular transport between endosomes and the trans-Golgi network. It is a vesicle-associated SNARE (v-SNARE) that interacts with target membrane SNAREs (t-SNAREs). Polymorphisms in this gene have been associated with binocular function, and also with susceptibility to colorectal and lung cancers. A recurrent rearrangement has been found between this gene and the transcription factor 7-like 2 (TCF7L2) gene in colorectal cancers. Alternative splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
143187
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using VTI1A antibody (CAB5162) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
