The VSIG4 Polyclonal Antibody (PAC051250) is a valuable tool for research involving VSIG4, a cell surface protein with immunomodulatory functions. This antibody is raised in rabbits and exhibits high reactivity with human samples, making it well-suited for use in Western blot applications. By binding to the VSIG4 protein, researchers can detect and analyze its expression in different cell types, making it ideal for studies in immunology and cancer research.VSIG4, also known as V-set and immunoglobulin domain containing 4, plays a crucial role in immune regulation by promoting immune tolerance and suppressing inflammatory responses.
Its involvement in immune modulation makes it a promising target for investigating diseases such as cancer, autoimmune disorders, and chronic inflammatory conditions. Understanding the function of VSIG4 is essential for developing novel therapeutic strategies that aim to manipulate immune responses in these disease contexts.
Immunohistochemistry of paraffin-embedded human lung tissue using PACO51250 at dilution of 1:100.
Immunofluorescent analysis of A549 cells using PACO51250 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
Background:
Phagocytic receptor, strong negative regulator of T-cell proliferation and IL2 production. Potent inhibitor of the alternative complement pathway convertases.
Synonyms:
V-set and immunoglobulin domain-containing protein 4 (Protein Z39Ig), VSIG4, CRIg Z39IG
UniProt Protein Function:
VSIG4: Phagocytic receptor, strong negative regulator of T-cell proliferation and IL2 production. Potent inhibitor of the alternative complement pathway convertases. 3 isoforms of the human protein are produced by alternative splicing.Protein type: Membrane protein, integral; Receptor, misc.Chromosomal Location of Human Ortholog: Xq12-q13.3
UniProt Protein Details:
NCBI Summary:
This gene encodes a v-set and immunoglobulin-domain containing protein that is structurally related to the B7 family of immune regulatory proteins. The encoded protein may be a negative regulator of T-cell responses. This protein is also a receptor for the complement component 3 fragments C3b and iC3b. Alternate splicing results in multiple transcript variants. [provided by RefSeq, May 2010]
