The VPX Antibody (PACO34318) is a powerful tool for researchers studying the VPX protein, a key player in the HIV replication process. This polyclonal antibody, produced in rabbits, is highly specific and reactive with human samples, making it ideal for use in Western blot and immunohistochemistry applications. By targeting the VPX protein, researchers can gain valuable insights into the mechanisms of HIV replication and potentially develop new treatments to combat the virus.The VPX protein is known for its role in facilitating viral infection and evading host immune responses. By targeting VPX with this antibody, researchers can study how the protein interacts with host cells and identify potential vulnerabilities that could be exploited for therapeutic purposes.
Understanding the function of VPX is essential for developing effective strategies to prevent HIV transmission and overcome drug resistance.Overall, the VPX Antibody (PACO34318) offers researchers a reliable tool for investigating the mechanisms of HIV replication and developing new approaches for treating and preventing infection. Its high specificity and reactivity make it a valuable asset for studies in virology, immunology, and infectious disease research.
Antibody Name:
vpx Antibody (PACO34318)
Antibody SKU:
PACO34318
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA
Recommended Dilutions:
Species Reactivity:
Human immunodeficiency virus type 2 subtype A
Immunogen:
Recombinant Human immunodeficiency virus type 2 subtype A Protein Vpx protein (1-113AA)
Plays a role in nuclear translocation of the viral pre-integration complex (PIC), thus is required for the virus to infect non-dividing cells. Targets specific host proteins for degradation by the 26S proteasome. Acts by associating with the cellular CUL4A-DDB1 E3 ligase complex through direct interaction with host VPRPB/DCAF-1. This change in the E3 ligase substrate specificity results in the degradation of host SAMHD1. In turn, SAMHD1 depletion allows viral replication in host myeloid cells by preventing SAMHD1-mediated hydrolysis of intracellular dNTPs necessary for reverse transcription.
Synonyms:
Protein Vpx (Viral protein X) (X ORF protein), vpx
UniProt Protein Function:
Plays a role in nuclear translocation of the viral pre-integration complex (PIC), thus is required for the virus to infect non-dividing cells. Targets specific host proteins for degradation by the 26S proteasome. Acts by associating with the cellular CUL4A-DDB1 E3 ligase complex through direct interaction with host VPRPB/DCAF-1. This change in the E3 ligase substrate specificity results in the degradation of host SAMHD1. In turn, SAMHD1 depletion allows viral replication in host myeloid cells by preventing SAMHD1-mediated hydrolysis of intracellular dNTPs necessary for reverse transcription.
