The VPX Antibody (PAC034282) is a polyclonal antibody designed for research involving the VPX protein, a key component in the viral cycle of HIV-2 and SIV. The antibody, generated in rabbits, is highly specific and validated for use in various experimental applications, including Western blot and immunofluorescence. It binds to the VPX protein, allowing for precise detection and analysis in cell cultures and tissue samples, making it an essential tool for virology and infectious disease research.VPX is a crucial accessory protein in the replication of HIV-2 and SIV viruses, facilitating viral genome integration into the host cell genome.
Understanding the function and interactions of VPX is essential for developing targeted drugs and therapies against HIV and related retroviruses. The VPX Antibody enables researchers to investigate the role of VPX in viral pathogenesis and host immune response, providing valuable insights into potential treatment strategies for HIV/AIDS and related infections.
Antibody Name:
vpx Antibody (PACO34282)
Antibody SKU:
PACO34282
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA
Recommended Dilutions:
Species Reactivity:
Simian immunodeficiency virus
Immunogen:
Recombinant Simian immunodeficiency virus Protein Vpx protein (1-112AA)
Plays a role in nuclear translocation of the viral pre-integration complex (PIC), thus is required for the virus to infect non-dividing cells. Targets specific host proteins for degradation by the 26S proteasome. Acts by associating with the cellular CUL4A-DDB1 E3 ligase complex through direct interaction with host VPRPB/DCAF-1. This change in the E3 ligase substrate specificity results in the degradation of host SAMHD1. In turn, SAMHD1 depletion allows viral replication in host myeloid cells by preventing SAMHD1-mediated hydrolysis of intracellular dNTPs necessary for reverse transcription.
Synonyms:
Protein Vpx (Viral protein X) (X ORF protein), vpx
UniProt Protein Function:
Plays a role in nuclear translocation of the viral pre-integration complex (PIC), thus is required for the virus to infect non-dividing cells. Targets specific host proteins for degradation by the 26S proteasome. Acts by associating with the cellular CUL4A-DDB1 E3 ligase complex through direct interaction with host VPRPB/DCAF-1. This change in the E3 ligase substrate specificity results in the degradation of host SAMHD1. In turn, SAMHD1 depletion allows viral replication in host myeloid cells by preventing SAMHD1-mediated hydrolysis of intracellular dNTPs necessary for reverse transcription.
