vpx Antibody (PACO34282)
- SKU:
- PACO34282
- Product Type:
- Antibody
- Reactivity:
- Virus
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | vpx Antibody (PACO34282) |
Antibody SKU: | PACO34282 |
Size: | 50ug |
Host Species: | Rabbit |
Tested Applications: | ELISA |
Recommended Dilutions: | |
Species Reactivity: | Simian immunodeficiency virus |
Immunogen: | Recombinant Simian immunodeficiency virus Protein Vpx protein (1-112AA) |
Form: | Liquid |
Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
Purification Method: | >95%, Protein G purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Background: | Plays a role in nuclear translocation of the viral pre-integration complex (PIC), thus is required for the virus to infect non-dividing cells. Targets specific host proteins for degradation by the 26S proteasome. Acts by associating with the cellular CUL4A-DDB1 E3 ligase complex through direct interaction with host VPRPB/DCAF-1. This change in the E3 ligase substrate specificity results in the degradation of host SAMHD1. In turn, SAMHD1 depletion allows viral replication in host myeloid cells by preventing SAMHD1-mediated hydrolysis of intracellular dNTPs necessary for reverse transcription. |
Synonyms: | Protein Vpx (Viral protein X) (X ORF protein), vpx |
UniProt Protein Function: | Plays a role in nuclear translocation of the viral pre-integration complex (PIC), thus is required for the virus to infect non-dividing cells. Targets specific host proteins for degradation by the 26S proteasome. Acts by associating with the cellular CUL4A-DDB1 E3 ligase complex through direct interaction with host VPRPB/DCAF-1. This change in the E3 ligase substrate specificity results in the degradation of host SAMHD1. In turn, SAMHD1 depletion allows viral replication in host myeloid cells by preventing SAMHD1-mediated hydrolysis of intracellular dNTPs necessary for reverse transcription. |
UniProt Protein Details: | |
NCBI Summary: | |
UniProt Code: | P19508 |
NCBI GenInfo Identifier: | 139461 |
NCBI Gene ID: | |
NCBI Accession: | P19508.1 |
UniProt Secondary Accession: | P19508 |
UniProt Related Accession: | P19508 |
Molecular Weight: | 28.9 kDa |
NCBI Full Name: | Protein Vpx |
NCBI Synonym Full Names: | |
NCBI Official Symbol: | |
NCBI Official Synonym Symbols: | |
NCBI Protein Information: | |
UniProt Protein Name: | Protein Vpx |
UniProt Synonym Protein Names: | Viral protein X; X ORF protein |
Protein Family: | Protein |
UniProt Gene Name: | vpx  |
UniProt Entry Name: | VPX_SIVSP |