The VPX Antibody (PACO34202) is a high-quality polyclonal antibody designed for research involving the VPX protein. VPX is a key factor in the life cycle of certain viruses, including HIV-2 and SIV, where it functions in the packaging of viral RNA. The antibody, raised in rabbits, exhibits strong reactivity with human samples and has been validated for use in Western blot applications. It specifically targets the VPX protein, allowing for precise detection and analysis in a variety of cell types.
VPX is a crucial component in viral replication and pathogenesis, making it a valuable target for research in virology and antiviral drug development. Understanding the role of VPX in viral infections can provide insights into the mechanisms of viral replication and help in the development of targeted therapies and vaccines. The VPX Antibody is a powerful tool for studying VPX function and its impact on viral pathogenesis, making it an essential asset in infectious disease research.
Antibody Name:
vpx Antibody (PACO34202)
Antibody SKU:
PACO34202
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA
Recommended Dilutions:
Species Reactivity:
Simian immunodeficiency virus
Immunogen:
Recombinant Simian immunodeficiency virus Protein Vpx protein (1-112AA)
Plays a role in nuclear translocation of the viral pre-integration complex (PIC), thus is required for the virus to infect non-dividing cells. Targets specific host proteins for degradation by the 26S proteasome. Acts by associating with the cellular CUL4A-DDB1 E3 ligase complex through direct interaction with host VPRPB/DCAF-1. This change in the E3 ligase substrate specificity results in the degradation of host SAMHD1. In turn, SAMHD1 depletion allows viral replication in host myeloid cells by preventing SAMHD1-mediated hydrolysis of intracellular dNTPs necessary for reverse transcription.
Synonyms:
Protein Vpx (Viral protein X) (X ORF protein), vpx
UniProt Protein Function:
Plays a role in nuclear translocation of the viral pre-integration complex (PIC), thus is required for the virus to infect non-dividing cells. Targets specific host proteins for degradation by the 26S proteasome. Acts by associating with the cellular CUL4A-DDB1 E3 ligase complex through direct interaction with host VPRPB/DCAF-1. This change in the E3 ligase substrate specificity results in the degradation of host SAMHD1. In turn, SAMHD1 depletion allows viral replication in host myeloid cells by preventing SAMHD1-mediated hydrolysis of intracellular dNTPs necessary for reverse transcription ().
