The VPS50 Polyclonal Antibody (PAC040154) is a powerful tool for researchers studying VPS50, a key protein involved in the endosomal sorting complex required for transport (ESCRT) pathway. This antibody, produced in rabbits, demonstrates high reactivity with human samples and has been validated for use in Western blot applications. By targeting the VPS50 protein, this antibody allows for the detection and analysis of VPS50 in various cell types, making it an essential tool for studies in cell biology and molecular biology.VPS50 is a critical player in the ESCRT pathway, which is responsible for sorting and trafficking proteins within cells.
Dysfunction in this pathway has been implicated in various diseases, including cancer and neurodegenerative disorders. By understanding the role of VPS50, researchers can gain valuable insights into how cellular trafficking processes are regulated and how they may be targeted for therapeutic interventions. The VPS50 Polyclonal Antibody is a valuable resource for studying the ESCRT pathway and its implications in various cellular processes and diseases.
Immunohistochemistry of paraffin-embedded human melanoma using PACO40154 at dilution of 1:100.
Immunohistochemistry of paraffin-embedded human brain tissue using PACO40154 at dilution of 1:100.
Background:
Acts as component of the EARP complex that is involved in endocytic recycling. The EARP complex associates with Rab4-positive endosomes and promotes recycling of internalized transferrin receptor (TFRC) to the plasma membrane. Within the EARP complex, required to tether the complex to recycling endosomes. Not involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN).
CCDC132: 2 isoforms of the human protein are produced by alternative splicing.Protein type: Unknown functionChromosomal Location of Human Ortholog: 7q21.3Cellular Component: membrane; recycling endosomeMolecular Function: SNARE bindingBiological Process: endocytic recycling; retrograde transport, endosome to Golgi
