The VPS37A Polyclonal Antibody (CAB7853) is a valuable tool for researchers studying VPS37A, a key protein involved in the endosomal sorting complex required for transport (ESCRT) machinery. This antibody, raised in rabbits, has been validated for use in Western blot applications and is highly reactive with human samples.VPS37A is essential for the proper function of the ESCRT machinery, which plays a crucial role in endosomal sorting and lysosomal degradation of cellular components. Dysregulation of VPS37A has been linked to various diseases, including neurodegenerative disorders and viral infections.
By detecting and analyzing VPS37A protein levels, researchers can gain insights into the mechanisms of ESCRT-mediated processes and their implications in disease pathogenesis.The VPS37A Polyclonal Antibody is an invaluable tool for investigating the role of VPS37A in cellular processes and disease development. Its specificity and sensitivity make it ideal for studies in cell biology, virology, and neurobiology, providing researchers with a deeper understanding of ESCRT function and its impact on human health.
Product Name:
VPS37A Rabbit Polyclonal Antibody
SKU:
CAB7853
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 224-397 of human VPS37A (NP_689628.2).
Late endosome membrane, Nucleus, Peripheral membrane protein.
Calculated MW:
44kDa
Observed MW:
44kDa
This gene belongs to the VPS37 family, and encodes a component of the ESCRT-I (endosomal sorting complex required for transport I) protein complex, required for the sorting of ubiquitinated transmembrane proteins into internal vesicles of multivesicular bodies. Expression of this gene is downregulated in hepatocellular carcinoma, and mutations in this gene are associated with autosomal recessive spastic paraplegia-53. A related pseudogene has been identified on chromosome 5. Alternatively spliced transcript variants have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
137492
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using VPS37A antibody (CAB7853) at 1:1000 dilution._Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution._Lysates/proteins: 25μg per lane._Blocking buffer: 3% nonfat dry milk in TBST._Detection: ECL Enhanced Kit (AbGn00021)._Exposure time: 30s.
