The VPS36 Polyclonal Antibody (PAC020867) is a valuable tool for researchers studying VPS36, a key component of the endosomal sorting complex required for transport (ESCRT) machinery. This antibody, produced in rabbits, demonstrates high reactivity with human samples and is validated for use in Western blot applications. By binding specifically to the VPS36 protein, this antibody enables accurate detection and analysis in a variety of cell types, making it an essential tool for research in cell biology and molecular biology.VPS36 is essential for the sorting of ubiquitinated membrane proteins into intraluminal vesicles of multivesicular bodies, playing a critical role in endosomal trafficking and protein degradation pathways.
Dysregulation of VPS36 has been linked to various diseases, including neurodegenerative disorders and viral infections. By investigating the functions and interactions of VPS36, researchers can gain insights into the mechanisms underlying these diseases and potentially identify new therapeutic targets.Overall, the VPS36 Polyclonal Antibody offers researchers a reliable tool for studying the role of VPS36 in cellular processes and disease pathology. Its high specificity and sensitivity make it an ideal choice for advancing our understanding of endosomal trafficking and protein degradation pathways, with potential implications for the development of novel therapeutics.
Antibody Name:
VPS36 Antibody (PACO20867)
Antibody SKU:
PACO20867
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:10000, IHC:1:30-1:150
Species Reactivity:
Human, Mouse, Rat
Immunogen:
Synthetic peptide of human VPS36
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human prostate cancer tissue using PACO20867(VPS36 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: x200).
The image on the left is immunohistochemistry of paraffin-embedded Human breast cancer tissue using PACO20867(VPS36 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
This gene encodes a protein that is a subunit of the endosomal sorting complex required for transport II (ESCRT-II). This protein complex functions in sorting of ubiquitinated membrane proteins during endocytosis. A similar protein complex in rat is associated with RNA polymerase elongation factor II.
Synonyms:
vacuolar protein sorting 36 homolog (S. cerevisiae)
