VPS33A Antibody (PACO17441)
- SKU:
- PACO17441
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Frequently bought together:
Description
| Antibody Name: | VPS33A Antibody (PACO17441) |
| Antibody SKU: | PACO17441 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:5000, IHC:1:25-1:100 |
| Species Reactivity: | Human, Mouse, Rat |
| Immunogen: | Fusion protein of human VPS33A |
| Form: | Liquid |
| Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| Purification Method: | Antigen affinity purification |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | The image on the left is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using PACO17441(VPS33A Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: x200). |
 | The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO17441(VPS33A Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: x200). |
| Background: | Vesicle mediated protein sorting plays an important role in segregation of intracellular molecules into distinct organelles. Genetic studies in yeast have identified more than 40 vacuolar protein sorting (VPS) genes involved in vesicle transport to vacuoles. This gene is a member of the Sec-1 domain family, and it encodes a protein similar to the yeast class C Vps33 protein. The mammalian class C VPS proteins are predominantly associated with late endosomes/lysosomes, and like their yeast counterparts, may mediate vesicle trafficking steps in the endosome/lysosome pathway. |
| Synonyms: | vacuolar protein sorting 33 homolog A (S. cerevisiae) |
| UniProt Protein Function: | |
| UniProt Protein Details: | |
| NCBI Summary: | This gene encodes a tethering protein and a core subunit of the homotypic fusion and protein sorting (HOPS) complex. The HOPS complex and a second endosomal tethering complex called the class C core vacuole/endosome tethering (CORVET) complex, perform diverse functions in endocytosis including membrane tethering, RabGTPase interaction, activation and proofreading of synaptic-soluble N-ethylmaleimide-sensitive factor attachment receptor (SNARE) assembly to drive membrane fusion, and endosome-to-cytoskeleton attachment. The HOPS complex controls endosome maturation as well as endosome traffic to the lysosome. This complex is essential for vacuolar fusion and is required for adaptor protein complex 3-dependent transport from the golgi to the vacuole. The encoded protein belongs to the Sec1/Munc18 (SM) family of SNARE-mediated membrane fusion regulators. Naturally occurring mutations in this gene are associated with a novel mucopolysaccharidosis-like disease. [provided by RefSeq, Apr 2017] |
| UniProt Code: | Q96AX1 |
| NCBI GenInfo Identifier: | 18105056 |
| NCBI Gene ID: | 65082 |
| NCBI Accession: | NP_075067 |
| UniProt Secondary Accession: | Q96AX1 |
| UniProt Related Accession: | Q96AX1 |
| Molecular Weight: | Observed: 68 kDaPredicted: 68 kDa |
| NCBI Full Name: | vacuolar protein sorting-associated protein 33A isoform 1 |
| NCBI Synonym Full Names: | VPS33A core subunit of CORVET and HOPS complexes |
| NCBI Official Symbol: | VPS33AÂ Â |
| NCBI Official Synonym Symbols: | MPSPSÂ Â |
| NCBI Protein Information: | vacuolar protein sorting-associated protein 33A |
| UniProt Protein Name: | Vacuolar protein sorting-associated protein 33A |
| UniProt Synonym Protein Names: | |
| Protein Family: | Vacuolar protein sorting-associated protein |
| UniProt Gene Name: | VPS33AÂ Â |
| UniProt Entry Name: | VP33A_HUMAN |
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