The VPS16 Antibody (PAC053898) is a high-quality polyclonal antibody designed for research involving VPS16, a key protein involved in vesicle trafficking pathways within cells. This antibody, raised in rabbits, is highly specific and reacts strongly with human samples, making it ideal for use in Western blot applications. It binds specifically to the VPS16 protein, allowing for accurate detection and analysis in various cell types.VPS16 is a critical component of the endosomal sorting complex required for transport (ESCRT) machinery, which plays a crucial role in sorting and trafficking proteins within cells. Dysregulation of this pathway has been implicated in various diseases, including cancer, neurodegenerative disorders, and viral infections.
By studying VPS16 and its interactions, researchers can gain valuable insights into these diseases and potentially uncover new therapeutic targets.This VPS16 antibody is a valuable tool for scientists conducting research in cell biology, molecular biology, and biomedicine. Its high specificity and sensitivity make it a reliable choice for experiments aimed at understanding the biological functions of VPS16 and its role in cellular processes. Order now and advance your research with this high-quality antibody from Assay Genie.
Western Blot. Positive WB detected in: Rat lung tissue. All lanes: VPS16 antibody at 3µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 95, 79 kDa. Observed band size: 95 kDa.
Immunohistochemistry of paraffin-embedded human brain tissue using PACO53898 at dilution of 1:100.
Immunohistochemistry of paraffin-embedded human lung tissue using PACO53898 at dilution of 1:100.
Background:
Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes which are proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The HOPS complex is proposed to be recruited to Rab7 on the late endosomal membrane and to regulate late endocytic, phagocytic and autophagic traffic towards lysosomes. The CORVET complex is proposed to function as a Rab5 effector to mediate early endosome fusion probably in specific endosome subpopulations. Required for recruitment of VPS33A to the HOPS complex. Required for fusion of endosomes and autophagosomes with lysosomes; the function is dependent on its association with VPS33A but not VPS33B. The function in autophagosome-lysosome fusion implicates STX17 but not UVRAG.
Synonyms:
Vacuolar protein sorting-associated protein 16 homolog (hVPS16), VPS16
