The VPREB3 Antibody (PAC013184) is a valuable tool for researchers studying VPREB3, a protein involved in B cell development and antibody production. This polyclonal antibody, raised in rabbits, is highly specific to human VPREB3 and has been validated for use in various applications, including Western blotting.VPREB3, also known as Ig-alpha protein, plays a critical role in the early stages of B cell development by forming a complex with Ig-beta to regulate B cell receptor signaling.
Dysregulation of VPREB3 has been implicated in autoimmune diseases and B cell malignancies, making it a promising target for therapeutic interventions.This antibody enables the detection and analysis of VPREB3 in different cell types, providing insight into its function and potential therapeutic implications. Researchers in the fields of immunology and cancer biology will find this antibody essential for their studies on B cell development and antibody production pathways.
VPREB3: Associates with the Ig-mu chain to form a molecular complex that is expressed on the surface of pre-B-cells. Belongs to the immunoglobulin superfamily.Protein type: Secreted; Secreted, signal peptideChromosomal Location of Human Ortholog: 22q11.23|22q11Cellular Component: endoplasmic reticulum; extracellular spaceBiological Process: immune response; immunoglobulin production
UniProt Protein Details:
NCBI Summary:
The protein encoded by this gene is the human ortholog of the mouse VpreB3 (8HS20) protein, is thought to be involved in B-cell maturation, and may play a role in assembly of the pre-B cell receptor (pre-BCR). While the role of this protein in B-cell development has not yet been elucidated, studies with the chicken ortholog of this protein have found that when overexpressed, this protein localizes to the endoplasmic reticulum. The mouse ortholog of this protein has been shown to associate with membrane mu heavy chains early in the course of pre-B cell receptor biosynthesis. Expression of this gene has been observed in some lymphomas. [provided by RefSeq, Apr 2015]
