The VP35 Polyclonal Antibody (PACO40042) is a valuable tool for researchers studying VP35, a key protein involved in the pathogenesis of Ebola virus. This antibody, generated in rabbits, is highly specific for human VP35 samples and has been validated for use in Western blot applications. By binding to VP35, the antibody allows for the detection and analysis of this important viral protein in various experimental settings, making it essential for investigations into the mechanisms of Ebola virus replication and immune evasion.VP35 is a multifunctional protein that plays a crucial role in the life cycle of Ebola virus, serving as a key component of the viral RNA polymerase complex and also acting as a viral replication inhibitor.
Understanding the function and interactions of VP35 is essential for the development of targeted antiviral therapies and vaccines against Ebola virus. The VP35 Polyclonal Antibody provides researchers with a reliable tool for investigating the role of VP35 in viral pathogenesis and immune evasion, ultimately contributing to the development of strategies to combat this deadly infectious disease.
Antibody Name:
VP35 Antibody (PACO40042)
Antibody SKU:
PACO40042
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA
Recommended Dilutions:
Species Reactivity:
Reston ebolavirus
Immunogen:
Recombinant Reston ebolavirus Polymerase cofactor VP35 protein (1-329AA)
Acts as a polymerase cofactor in the RNA polymerase transcription and replication complex. Prevents establishment of cellular antiviral state by blocking virus-induced phosphorylation and activation of interferon regulatory factor 3 (IRF3), a transcription factor critical for the induction of interferons α and beta. This blockage is produced through the interaction with and inhibition host IKBKE and TBK1 producing a strong inhibition of the phosphorylation and activation of IRF3. Also inhibits the antiviral effect mediated by the interferon-induced, double-stranded RNA-activated protein kinase EIF2AK2/PKR.
Synonyms:
Polymerase cofactor VP35, VP35
UniProt Protein Function:
Acts as a polymerase cofactor in the RNA polymerase transcription and replication complex. Prevents establishment of cellular antiviral state by blocking virus-induced phosphorylation and activation of interferon regulatory factor 3 (IRF3), a transcription factor critical for the induction of interferons alpha and beta. This blockage is produced through the interaction with and inhibition host IKBKE and TBK1 producing a strong inhibition of the phosphorylation and activation of IRF3. Also inhibits the antiviral effect mediated by the interferon-induced, double-stranded RNA-activated protein kinase EIF2AK2/PKR ().
