VOPP1 Antibody (PACO31712)
- SKU:
- PACO31712
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- WB
- IF
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
VOPP1 Antibody (PACO31712)
The VOPP1 Polyclonal Antibody (PACO31712) is a valuable tool for researchers studying the VOPP1 protein, a key player in cell growth and survival pathways. This antibody, generated in rabbits, exhibits high specificity and sensitivity towards VOPP1 in human samples, making it suitable for use in Western blot applications. By targeting the VOPP1 protein, this antibody enables the detection and analysis of VOPP1 expression in various cell types, facilitating investigations in cell biology and cancer research.VOPP1, also known as an oncogene and a regulator of apoptosis, is involved in promoting cell proliferation and suppressing programmed cell death.
Its dysregulation has been implicated in various cancers, emphasizing the importance of studying VOPP1 in cancer biology. Additionally, VOPP1 has been linked to other cellular processes such as autophagy and stress response, further highlighting its significance in cell physiology.By utilizing the VOPP1 Polyclonal Antibody, researchers can gain valuable insights into the role of VOPP1 in cancer development and progression, as well as its potential as a therapeutic target. Understanding the function of VOPP1 is essential for advancing our knowledge of cancer biology and developing novel treatment strategies for cancer patients.
| Antibody Name: | VOPP1 Antibody (PACO31712) |
| Antibody SKU: | PACO31712 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IF |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:1000-1:5000, IF:1:50-1:200 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human Vesicular, overexpressed in cancer, prosurvival protein 1 protein (23-172AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western blot All lanes: VOPP1 antibody at 2µg/ml Lane 1: EC109 whole cell lysate Lane 2: 293T whole cell lysate Secondary Goat polyclonal to rabbit IgG at 1/15000 dilution Predicted band size: 20, 19, 18 kDa Observed band size: 50, 70, 80 kDa . |
 | Immunofluorescent analysis of HepG2 cells using PACO31712 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
| Background: | Increases the transcriptional activity of NFKB1 by facilitating its nuclear translocation, DNA-binding and associated apoptotic response, when overexpressed. |
| Synonyms: | Vesicular, overexpressed in cancer, prosurvival protein 1 (EGFR-coamplified and overexpressed protein) (ECop) (Glioblastoma-amplified secreted protein) (Putative NF-kappa-B-activating protein 055N), VOPP1, ECOP GASP |
| UniProt Protein Function: | ECOP: Increases the transcriptional activity of NFKB1 by facilitating its nuclear translocation, DNA-binding and associated apoptotic response, when overexpressed. Belongs to the VOPP1/ECOP family. 3 isoforms of the human protein are produced by alternative splicing.Protein type: Membrane protein, integralChromosomal Location of Human Ortholog: 7p11.2Cellular Component: cytoplasmic vesicle membrane; endosomeMolecular Function: signal transducer activity |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | Q96AW1 |
| NCBI GenInfo Identifier: | 74760714 |
| NCBI Gene ID: | 81552 |
| NCBI Accession: | Q96AW1.1 |
| UniProt Secondary Accession: | Q96AW1,Q6FIE3, Q8NBN8, Q96RE5, Q9H0W4, B0AZU1, B2RAT4 B3KS72, C9JWR3 |
| UniProt Related Accession: | Q96AW1 |
| Molecular Weight: | 17,381 Da |
| NCBI Full Name: | Vesicular, overexpressed in cancer, prosurvival protein 1 |
| NCBI Synonym Full Names: | vesicular, overexpressed in cancer, prosurvival protein 1 |
| NCBI Official Symbol: | VOPP1Â Â |
| NCBI Official Synonym Symbols: | ECOP; GASPÂ Â |
| NCBI Protein Information: | vesicular, overexpressed in cancer, prosurvival protein 1 |
| UniProt Protein Name: | Vesicular, overexpressed in cancer, prosurvival protein 1 |
| UniProt Synonym Protein Names: | EGFR-coamplified and overexpressed protein; ECop; Glioblastoma-amplified secreted protein; Putative NF-kappa-B-activating protein 055N |
| Protein Family: | Vesicular, overexpressed in cancer, prosurvival protein |
| UniProt Gene Name: | VOPP1Â Â |
| UniProt Entry Name: | VOPP1_HUMAN |
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