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Von Hippel Lindau/VHL Monoclonal Antibody (CAB23239)

SKU:
CAB23239
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Applications:
WB
€139 - €529
Frequently bought together:

Description

Von Hippel Lindau/VHL Monoclonal Antibody (CAB23239)

The Von Hippel-Lindau (VHL) Monoclonal Antibody (CAB23239) is a crucial tool for research involving the VHL protein, a tumor suppressor that plays a key role in the regulation of cell growth and division. This antibody, produced in mice, has high specificity for human samples and has been extensively validated for use in various applications, including immunohistochemistry and flow cytometry.The VHL protein is known for its role in the development of von Hippel-Lindau disease, a rare genetic disorder characterized by the formation of tumors in various organs.

Research into the function and regulation of VHL is essential for gaining insights into tumorigenesis and for the development of targeted therapies for VHL disease and related conditions.In summary, the VHL Monoclonal Antibody (CAB23239) is a valuable tool for scientists studying the VHL protein and its implications in cancer research and genetic disorders. Its high specificity and reliability make it a preferred choice for investigating the molecular mechanisms underlying tumorigenesis and potential therapeutic interventions.

Product Name:Von Hippel Lindau/VHL Monoclonal Antibody
Product Code:CAB23239
Reactivity:Human, Mouse, Rat
Applications:Western blotting
Host Species:Rabbit
Purification Method:Affinity purification
Isotype:IgG
Clone No:ARC59984
Reactivity:Human, Mouse, Rat
Tested Applications:WB, ELISA
Key Applications:Western blotting
Recommended Dilution:WB 1:500-1:1000
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 0.05% BSA, 50% glycerol, pH7.3.
Positive Samples:HeLa, 293T, Mouse brain, Mouse kidney, Rat brain, Rat kidney
Cellular Location:Cytoplasm, Membrane, Nucleus, Nucleus, Peripheral membrane protein

This gene encodes a component of a ubiquitination complex. The encoded protein is involved in the ubiquitination and degradation of hypoxia-inducible-factor (HIF), which is a transcription factor that plays a central role in the regulation of gene expression by oxygen. In addition to oxygen-related gene expression, this protein plays a role in many other cellular processes including cilia formation, cytokine signaling, regulation of senescence, and formation of the extracellular matrix. Variants of this gene are associated with von Hippel-Lindau syndrome, pheochromocytoma, erythrocytosis, renal cell carcinoma, and cerebellar hemangioblastoma.

Immunogen:Recombinant protein of human Von Hippel Lindau/VHL.
Sequence:Email for sequence
Synonyms:RCA1, VHL1, pVHL, HRCA1
Calculated MW:24kDa
Observed MW:18-24kDa

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