The VN1R1 Polyclonal Antibody (PAC061145) is a valuable tool for researchers studying VN1R1, a member of the vomeronasal receptor gene family involved in olfactory communication. This antibody, produced in rabbits, exhibits high specificity and reactivity with human samples, making it suitable for use in various applications including Western blotting. By targeting the VN1R1 protein, this antibody allows for the detection and analysis of VN1R1 expression in different cell types, making it ideal for studies in neuroscience and sensory biology.
VN1R1 is a key player in the detection of pheromones and other chemical signals, playing a crucial role in social behavior and reproductive physiology. Its involvement in the olfactory system makes it a promising target for research in fields such as neuroscience, psychology, and evolutionary biology. Understanding the function of VN1R1 can provide insights into the mechanisms underlying communication and behavior in various species, offering potential implications for studies on social interactions and mating preferences.
Western Blot. Positive WB detected in: Hela whole cell lysate, LO2 whole cell lysate, A549 whole cell lysate, PC-3 whole cell lysate. All lanes: VN1R1 antibody at 3.3µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 41 kDa. Observed band size: 41 kDa.
Immunofluorescence staining of Hela cells with PACO61145 at 1:133, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
VN1R1: Putative pheromone receptor. Belongs to the G-protein coupled receptor 1 family.Protein type: Membrane protein, multi-pass; Receptor, GPCR; Membrane protein, integral; GPCR, family 1Chromosomal Location of Human Ortholog: 19q13.4Cellular Component: plasma membrane; integral to membraneMolecular Function: pheromone receptor activityBiological Process: G-protein coupled receptor protein signaling pathway; response to pheromone
UniProt Protein Details:
NCBI Summary:
Pheromones are chemical signals that elicit specific behavioral responses and physiologic alterations in recipients of the same species. The protein encoded by this gene is similar to pheromone receptors and is primarily localized to the olfactory mucosa. An alternate splice variant of this gene is thought to exist, but its full length nature has not been determined. [provided by RefSeq, Jul 2008]
