The VLDLR Polyclonal Antibody (CAB7345) is a valuable tool for researchers studying the very low-density lipoprotein receptor (VLDLR), a key protein involved in lipid metabolism and neuronal development. This antibody, generated in rabbits, has high specificity for the VLDLR protein in human samples and has been validated for use in Western blot experiments. By binding to VLDLR, this antibody allows for the detection and analysis of this important receptor in various cell types, making it perfect for investigations in neurobiology and cardiovascular research.
The VLDLR protein is essential for the uptake of triglyceride-rich lipoproteins and plays a crucial role in lipid homeostasis. In addition, VLDLR has been implicated in neuronal migration and synaptic plasticity, highlighting its importance in brain development and function. Research into the function of VLDLR is key for understanding its role in metabolic disorders, neurodegenerative diseases, and cardiovascular conditions, with the potential to uncover novel therapeutic strategies for these conditions.
Product Name:
VLDLR Rabbit Polyclonal Antibody
SKU:
CAB7345
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 833-869 of human VLDLR (NP_003374.3).
Sequence:
DNPV YLKT TEED LSID IGRH SASV GHTY PAIS VVST D
Tested Applications:
WBELISA
Recommended Dilution:
WB,1:500 - 1:2000
Synonyms:
CAMRQ1; CARMQ1; CHRMQ1; VLDL-R; VLDLRCH; VLDLR
Positive Sample:
THP-1,Mouse lung,Mouse ovary
Conjugate:
Unconjugated
Cellular Localization:
Membrane, Single-pass type I membrane protein, clathrin-coated pit.
Calculated MW:
96kDa
Observed MW:
110kDa
The low density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. This gene encodes a lipoprotein receptor that is a member of the LDLR family and plays important roles in VLDL-triglyceride metabolism and the reelin signaling pathway. Mutations in this gene cause VLDLR-associated cerebellar hypoplasia. Alternative splicing generates multiple transcript variants encoding distinct isoforms for this gene.
Purification Method:
Affinity purification
Gene ID:
7436
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using VLDLR antibody (CAB7345) at 1:1000 dilution._Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution._Lysates/proteins: 25μg per lane._Blocking buffer: 3% nonfat dry milk in TBST._Detection: ECL Enhanced Kit (AbGn00021)._Exposure time: 90s.
