The Vitronectin Rabbit Monoclonal Antibody (CAB4883) is a valuable tool for researchers studying vitronectin, a glycoprotein involved in cell adhesion and migration processes. This antibody, produced in rabbits, demonstrates high specificity and sensitivity for detecting vitronectin in various samples, particularly in Western blot applications.Vitronectin plays a crucial role in cell adhesion, migration, and regulation of the coagulation cascade, making it a key player in processes such as wound healing, tissue remodeling, and angiogenesis. Dysregulation of vitronectin expression has been implicated in various diseases, including cancer, cardiovascular disorders, and inflammatory conditions.
With the Vitronectin Rabbit Monoclonal Antibody (CAB4883), researchers can accurately detect and analyze vitronectin expression in different cell types and tissues, facilitating investigations into its role in normal physiological processes and disease pathogenesis. This antibody is a valuable tool for studies in cell biology, cancer research, and vascular biology, offering insights that may lead to the development of novel therapeutic strategies targeting vitronectin-related pathways.
Product Name:
Vitronectin Rabbit Monoclonal Antibody
SKU:
CAB4883
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 379-478 of human Vitronectin (P04004).
The protein encoded by this gene functions in part as an adhesive glycoprotein. Differential expression of this protein can promote either cell adhesion or migration as it links cells to the extracellular matrix through a variety of ligands. These ligands include integrins, plasminogen activator inhibitor-1, and urokinase plasminogen activator receptor. This secreted protein can be present in the plasma as a monomer or dimer and forms a multimer in the extracellular matrix of several tissues. This protein also inhibits the membrane-damaging effect of the terminal cytolytic complement pathway and binds to several serpin serine protease inhibitors. This protein can also promote extracellular matrix degradation and thus plays a role in tumorigenesis. It is involved in a variety of other biological processes such as the regulation of the coagulation pathway, wound healing, and tissue remodeling. The heparin-binding domain of this protein give it anti-microbial properties. It is also a lipid binding protein that forms a principal component of high density lipoprotein.
Purification Method:
Affinity purification
Gene ID:
7448
Clone Number:
ARC0313
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of lysates from HepG2 cells, using Vitronectin Rabbit mAb (CAB4883) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 3min.
