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Vitronectin Rabbit Monoclonal Antibody (CAB4883)

SKU:
CAB4883
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
V75
VN
VNT
Research Area:
Cell Biology
  • Cell Biology Antibodies 17 Anti-Vitronectin Antibody CAB4883
  • Cell Biology Antibodies 17 Anti-Vitronectin Antibody CAB4883
$167 - $503
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Description

system_update_altDatasheetsystem_update_altMSDS
Product Name:Vitronectin Rabbit Monoclonal Antibody
SKU:CAB4883
Size:20uL, 100uL
Isotype:IgG
Host Species:Rabbit
Reactivity:Human
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 379-478 of human Vitronectin (P04004).
Sequence:YRSQ RGHS RGRN QNSR RPSR ATWL SLFS SEES NLGA NNYD DYRM DWLV PATC EPIQ SVFF FSGD KYYR VNLR TRRV DTVD PPYP RSIA QYWL GCPA PGHL
Tested Applications:WB ELISA
Recommended Dilution:WB,1:500 - 1:2000
Synonyms:VN; V75; VNT; Vitronectin
Positive Sample:HepG2
Conjugate:Unconjugated
Cellular Localization:Secreted, Extracellular space.
Calculated MW:54kDa
Observed MW:75kDa

The protein encoded by this gene functions in part as an adhesive glycoprotein. Differential expression of this protein can promote either cell adhesion or migration as it links cells to the extracellular matrix through a variety of ligands. These ligands include integrins, plasminogen activator inhibitor-1, and urokinase plasminogen activator receptor. This secreted protein can be present in the plasma as a monomer or dimer and forms a multimer in the extracellular matrix of several tissues. This protein also inhibits the membrane-damaging effect of the terminal cytolytic complement pathway and binds to several serpin serine protease inhibitors. This protein can also promote extracellular matrix degradation and thus plays a role in tumorigenesis. It is involved in a variety of other biological processes such as the regulation of the coagulation pathway, wound healing, and tissue remodeling. The heparin-binding domain of this protein give it anti-microbial properties. It is also a lipid binding protein that forms a principal component of high density lipoprotein.

Purification Method:Affinity purification
Gene ID:7448
Clone Number:ARC0313
Storage Buffer:Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Product ImageWestern blot analysis of lysates from HepG2 cells, using Vitronectin Rabbit mAb (CAB4883) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 3min.

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