The Vitronectin Polyclonal Antibody (CAB1667) is a vital tool for researchers studying the role of vitronectin, a glycoprotein involved in cell adhesion and migration. This antibody, produced in rabbits, demonstrates high reactivity with human samples and has been validated for Western blot applications. By specifically targeting the vitronectin protein, this antibody allows for the detection and analysis of vitronectin in various cell types, making it an excellent choice for studies in cell biology and cancer research.Vitronectin plays a crucial role in various biological processes, including wound healing, tissue remodeling, and angiogenesis.
Its involvement in cell migration and adhesion makes it a key player in cancer metastasis and tumor progression. Understanding the mechanisms and functions of vitronectin can provide valuable insights into cancer biology and facilitate the development of targeted therapies.Overall, the Vitronectin Polyclonal Antibody (CAB1667) represents a valuable tool for researchers seeking to further their knowledge of vitronectin's role in normal physiological processes and disease pathology. Its high reactivity and specificity make it a reliable resource for studies aiming to elucidate the intricate functions of vitronectin in various cellular contexts.
Product Name:
Vitronectin Rabbit Polyclonal Antibody
SKU:
CAB1667
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 364-478 of human Vitronectin (NP_000629.3).
The protein encoded by this gene functions in part as an adhesive glycoprotein. Differential expression of this protein can promote either cell adhesion or migration as it links cells to the extracellular matrix through a variety of ligands. These ligands include integrins, plasminogen activator inhibitor-1, and urokinase plasminogen activator receptor. This secreted protein can be present in the plasma as a monomer or dimer and forms a multimer in the extracellular matrix of several tissues. This protein also inhibits the membrane-damaging effect of the terminal cytolytic complement pathway and binds to several serpin serine protease inhibitors. This protein can also promote extracellular matrix degradation and thus plays a role in tumorigenesis. It is involved in a variety of other biological processes such as the regulation of the coagulation pathway, wound healing, and tissue remodeling. The heparin-binding domain of this protein give it anti-microbial properties. It is also a lipid binding protein that forms a principal component of high density lipoprotein.
Purification Method:
Affinity purification
Gene ID:
7448
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using Vitronectin Rabbit pAb (CAB1667) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 20s.
