The Vitamin D3 Receptor Polyclonal Antibody (CAB11737) is a valuable tool for researchers studying the role of the Vitamin D3 receptor in various biological processes. This antibody, raised in rabbits, specifically targets the Vitamin D3 receptor protein and is highly reactive with human samples. The Vitamin D3 receptor is a nuclear hormone receptor that plays a crucial role in regulating gene transcription in response to Vitamin D3. It is involved in diverse physiological functions such as calcium homeostasis, cell growth, differentiation, and immune response modulation. The use of this antibody is validated for applications such as Western blotting, immunofluorescence, and immunohistochemistry, allowing for the detection and analysis of the Vitamin D3 receptor in a variety of cell types and tissues.
Its high specificity and sensitivity make it an ideal reagent for studying the function and expression of the Vitamin D3 receptor in conditions such as vitamin D deficiency, autoimmune diseases, cancer, and other related disorders.Overall, the Vitamin D3 Receptor Polyclonal Antibody (CAB11737) is a valuable tool for researchers interested in understanding the role of the Vitamin D3 receptor in health and disease, and it offers great potential for advancing research in the fields of endocrinology, immunology, and oncology.
Product Name:
VDR Rabbit Polyclonal Antibody
SKU:
CAB11737
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-100 of human VDR (NP_000367.1).
This gene encodes vitamin D3 receptor, which is a member of the nuclear hormone receptor superfamily of ligand-inducible transcription factors. This receptor also functions as a receptor for the secondary bile acid, lithocholic acid. Downstream targets of vitamin D3 receptor are principally involved in mineral metabolism, though this receptor regulates a variety of other metabolic pathways, such as those involved in immune response and cancer. Mutations in this gene are associated with type II vitamin D-resistant rickets. A single nucleotide polymorphism in the initiation codon results in an alternate translation start site three codons downstream. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. A recent study provided evidence for translational readthrough in this gene, and expression of an additional C-terminally extended isoform via the use of an alternative in-frame translation termination codon.
Purification Method:
Affinity purification
Gene ID:
7421
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using VDR Rabbit pAb (CAB11737) at 1:500 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
