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VISTA / B7-H5 / GI24 Polyclonal Antibody

SKU:
CAB24535
Product Type:
Antibody
Antibody Type:
Polyclonal Antibody
Reactivity:
Human
Rat
Host Species:
Rabbit
Isotype:
IgG
Applications:
WB
IHC
€129 - €359
Frequently bought together:

Description

VISTA / B7-H5 / GI24 Polyclonal Antibody (CAB24535)

The VISTA/B7-H5/GI24 Polyclonal Antibody is a valuable tool for researchers studying immune regulation and immune responses. This antibody, developed through the immunization of rabbits, has been shown to be highly reactive with human samples and is specifically validated for use in Western blot applications.The VISTA/B7-H5/GI24 protein, also known as V-domain Ig suppressor of T cell activation (VISTA), plays a critical role in immune homeostasis by inhibiting T cell activation and promoting immune tolerance. Its significance in immune regulation makes it a promising target for research into diseases such as cancer, autoimmune disorders, and chronic inflammatory conditions.

By binding to the VISTA/B7-H5/GI24 protein, this polyclonal antibody enables researchers to detect and analyze its expression in various cell types, providing valuable insights into its role in immunology and cancer research. Understanding the mechanisms of VISTA/B7-H5/GI24 activity is essential for developing targeted therapies to modulate immune responses in disease contexts.Overall, the VISTA/B7-H5/GI24 Polyclonal Antibody is a valuable tool for researchers looking to explore the complex interplay of immune regulation and immune responses in health and disease.

Product Name:VISTA / B7-H5 / GI24 Polyclonal Antibody
Product Code:CAB24535
Reactivity:Human, Rat
Applications:Western blotting, Immunohistochemistry
Host Species:Rabbit
Purification Method:Affinity purification
Isotype:IgG
Reactivity:Human, Rat
Tested Applications:WB, IHC-P, ELISA
Key Applications:Western blotting, Immunohistochemistry
Recommended Dilution:WB 1:500-1:1000, IHC-P 1:50-1:200
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 50% glycerol, pH7.3.
Positive Samples:HLE, Rat spleen
Cellular Location:Cell membrane, Single-pass type I membrane protein

Enables endopeptidase activator activity; enzyme binding activity; and identical protein binding activity. Involved in several processes, including negative regulation of cytokine production; positive regulation of macromolecule metabolic process; and regulation of T cell activation. Located in plasma membrane.

Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 33-194 of human VISTA / B7-H5 / GI24 (NP_071436.1).
Sequence:FKVAT PYSLY VCPEG QNVTL TCRLL GPVDK GHDVT FYKTW YRSSR GEVQT CSERR PIRNL TFQDL HLHHG GHQAA NTSHD LAQRH GLESA SDHHG NFSIT MRNLT LLDSG LYCCL VVEIR HHHSE HRVHG AMELQ VQTGK DAPSN CVVYP SSSQD SENIT AA
Synonyms:VSIR, B7-H5, B7H5, C10orf54, DD1alpha, GI24, PD-1H, PP2135, SISP1, VISTA, V-set immunoregulatory receptor
Calculated MW:33kDa
Observed MW:45-65kDa

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