The VIPR2 Polyclonal Antibody (PACO20856) is a valuable tool for researchers studying the VIPR2 protein, which belongs to the vasoactive intestinal peptide receptor family. This antibody, produced in rabbits, has high reactivity with human samples and has been validated for use in Western blot applications. By specifically binding to VIPR2, this antibody allows for the detection and analysis of the protein in various cell types, making it ideal for investigations in neuroscience and endocrinology.
VIPR2 is a receptor for vasoactive intestinal peptide (VIP), a neuropeptide with diverse physiological roles including regulating circadian rhythm, neurotransmission, and immune response. Dysregulation of VIPR2 signaling has been implicated in various neurological and endocrine disorders, making it a promising target for therapeutic development. Understanding the function of VIPR2 is crucial for elucidating its role in these diseases and potentially identifying novel treatment strategies.
Antibody Name:
VIPR2 Antibody (PACO20856)
Antibody SKU:
PACO20856
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:5000, IHC:1:25-1:100
Species Reactivity:
Human, Mouse, Rat
Immunogen:
Synthetic peptide of human VIPR2
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using PACO20856(VIPR2 Antibody) at dilution 1/35, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
This gene encodes a receptor for vasoactive intestinal peptide, a small neuropeptide. Vasoactive intestinal peptide is involved in smooth muscle relaxation, exocrine and endocrine secretion, and water and ion flux in lung and intestinal epithelia. Its actions are effected through integral membrane receptors associated with a guanine nucleotide binding protein which activates adenylate cyclase.
Synonyms:
vasoactive intestinal peptide receptor 2
UniProt Protein Function:
VIPR2: This is a receptor for VIP as well as PACAP-38 and -27, the activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Can be coupled to phospholipase C. Belongs to the G-protein coupled receptor 2 family.
UniProt Protein Details:
Protein type:Receptor, GPCR; Membrane protein, integral; Membrane protein, multi-pass; GPCR, family 2
Chromosomal Location of Human Ortholog: 7q36.3
Cellular Component: integral to plasma membrane; plasma membrane
Biological Process: cell-cell signaling; signal transduction
NCBI Summary:
This gene encodes a receptor for vasoactive intestinal peptide, a small neuropeptide. Vasoactive intestinal peptide is involved in smooth muscle relaxation, exocrine and endocrine secretion, and water and ion flux in lung and intestinal epithelia. Its actions are effected through integral membrane receptors associated with a guanine nucleotide binding protein which activates adenylate cyclase. [provided by RefSeq, Aug 2011]
VPAC2; VPAC2R; VIP-R-2; VPCAP2R; PACAP-R3; DUP7q36.3; PACAP-R-3; C16DUPq36.3Â Â
NCBI Protein Information:
vasoactive intestinal polypeptide receptor 2
UniProt Protein Name:
Vasoactive intestinal polypeptide receptor 2
UniProt Synonym Protein Names:
Helodermin-preferring VIP receptor; Pituitary adenylate cyclase-activating polypeptide type III receptor; PACAP type III receptor; PACAP-R-3; PACAP-R3; VPAC2
