The VIPR1 Polyclonal Antibody (PAC020854) is a valuable tool for researchers studying the VIPR1 protein, a receptor involved in the regulation of vasoactive intestinal peptide (VIP). This antibody, produced in rabbits, is highly specific to human samples and has been validated for use in Western blot applications. By binding to VIPR1, this antibody allows for the detection and analysis of the receptor in various cell types, making it ideal for studies in neuroscience, endocrinology, and immunology.
VIPR1 plays a crucial role in various physiological processes, including neurotransmission, hormone secretion, and immune response modulation. Dysregulation of VIPR1 has been implicated in conditions such as neurodegenerative diseases, gastrointestinal disorders, and autoimmune conditions. By understanding the function of VIPR1, researchers can uncover new insights into these diseases and potentially develop targeted therapies to modulate VIP signaling for therapeutic benefit.
Antibody Name:
VIPR1 Antibody (PACO20854)
Antibody SKU:
PACO20854
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:1000-1:2000, IHC:1:10-1:50
Species Reactivity:
Human, Mouse, Rat
Immunogen:
Synthetic peptide of human VIPR1
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO20854(VIPR1 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
This gene encodes a receptor for vasoactive intestinal peptide, a small neuropeptide. Vasoactive intestinal peptide is involved in smooth muscle relaxation, exocrine and endocrine secretion, and water and ion flux in lung and intestinal epithelia. Its actions are effected through integral membrane receptors associated with a guanine nucleotide binding protein which activates adenylate cyclase. Several transcript variants encoding different isoforms have been found for this gene.
Synonyms:
vasoactive intestinal peptide receptor 1
UniProt Protein Function:
VIPR1: This is a receptor for VIP. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. The affinity is VIP = PACAP-27 > PACAP-38. Belongs to the G-protein coupled receptor 2 family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:
Protein type:Membrane protein, integral; Motility/polarity/chemotaxis; Membrane protein, multi-pass; GPCR, family 2; Receptor, GPCR
Chromosomal Location of Human Ortholog: 3p22
Cellular Component: integral to plasma membrane; plasma membrane; receptor complex
Molecular Function:vasoactive intestinal polypeptide receptor activity; protein binding
Biological Process: synaptic transmission; G-protein signaling, coupled to cyclic nucleotide second messenger; G-protein coupled receptor protein signaling pathway; muscle contraction; digestion; positive regulation of cell proliferation; immune response
NCBI Summary:
This gene encodes a receptor for vasoactive intestinal peptide, a small neuropeptide. Vasoactive intestinal peptide is involved in smooth muscle relaxation, exocrine and endocrine secretion, and water and ion flux in lung and intestinal epithelia. Its actions are effected through integral membrane receptors associated with a guanine nucleotide binding protein which activates adenylate cyclase. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
vasoactive intestinal polypeptide receptor 1; VIP receptor, type I; PACAP type II receptor; VIP and PACAP receptor 1; pituitary adenylate cyclase activating polypeptide receptor, type II
UniProt Protein Name:
Vasoactive intestinal polypeptide receptor 1
UniProt Synonym Protein Names:
Pituitary adenylate cyclase-activating polypeptide type II receptor; PACAP type II receptor; PACAP-R-2; PACAP-R2; VPAC1
