The VIMP Polyclonal Antibody (CAB15013) is a vital tool for researchers studying the VIMP protein, a key component involved in cellular processes such as protein quality control and ER stress response. This antibody, produced through immunization of rabbits, exhibits high specificity and sensitivity towards VIMP in human samples, making it suitable for Western blot applications.VIMP, also known as VCP-interacting membrane protein, is essential for maintaining cellular homeostasis and responding to various stress conditions within the endoplasmic reticulum. Dysregulation of VIMP has been linked to diseases such as neurodegenerative disorders and cancer, making it a promising target for therapeutic interventions.
By utilizing the VIMP Polyclonal Antibody, researchers can accurately detect and analyze VIMP expression levels in different cell types, providing valuable insights into the role of this protein in health and disease. This antibody is a valuable tool for studies in cell biology, molecular biology, and disease mechanisms, offering researchers the opportunity to further understand the intricate workings of the cell.
Product Name:
VIMP Rabbit Polyclonal Antibody
SKU:
CAB15013
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 50-150 of human VIMP (NP_982298.2).
This gene encodes a transmembrane protein that is localized in the endoplasmic reticulum (ER). It is involved in the degradation process of misfolded proteins in the ER, and may also have a role in inflammation control. This protein is a selenoprotein, containing the rare amino acid selenocysteine (Sec). Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Two additional phylogenetically conserved stem-loop structures (Stem-loop 1 and Stem-loop 2) in the 3' UTR of this mRNA have been shown to function as modulators of Sec insertion. An alternatively spliced transcript variant, lacking the SECIS element and encoding a non-Sec containing shorter isoform, has been described for this gene (PMID:23614019).
Purification Method:
Affinity purification
Gene ID:
55829
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of Rat testis, using VIMP Rabbit pAb (CAB15013) at 1:2000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
