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Vimentin PAT5H8AT Monoclonal Antibody [PAT5H8AT] (CPAB0668)

SKU:
CPAB0668
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Universal
Host Species:
Mouse
Isotype:
IgG1
Clone:
PAT5H8AT
Applications:
WB
ELISA
FC
€149
Frequently bought together:

Description

system_update_alt Datasheet

Vimentin PAT5H8AT Monoclonal Antibody [PAT5H8AT] (CPAB0668)

The Vimentin PAT5H8AT Antibody (CPAB0668) is a valuable tool for researchers studying vimentin, a protein essential for maintaining cell integrity and structure. This polyclonal antibody, produced in rabbits, exhibits a high reactivity with human vimentin samples and has been validated for use in various applications, including Western blotting.Vimentin is a key intermediate filament protein that plays a crucial role in cell migration, adhesion, and signaling pathways. Its expression is often altered in cancer cells, making it a relevant target for cancer research and potential therapeutic interventions.

The Vimentin PAT5H8AT Antibody allows for the specific detection and analysis of vimentin in different cell types, providing valuable insights into its function and involvement in various cellular processes.By using this antibody, researchers can further explore the role of vimentin in physiological and pathological conditions, leading to a better understanding of its potential as a biomarker or therapeutic target in diseases such as cancer and fibrosis. Its versatility and specificity make it an essential tool for advancing research in cell biology and biomedicine.

Product Name:Vimentin PAT5H8AT Antibody
Product Sku:CPAB0668
Size:5μg
Host Species:Mouse
Immunogen:Anti-human Vimentin mAb, is derived from hybridization of mouse F myeloma cells with spleen cells from BALB/c mice immunized with a recombinant human Vimentin protein 1-466 amino acids purified from Ecoli.
Clone:PAT5H8AT.
Reactivity:Other bodies
Applications:Western Blot, ELISA, Flow Cytometry
Purification Method:Vimentin antibody was purified from mouse ascitic fluids by protein-A affinity chromatography.
Isotype:IgG1
Background:Vimentin expression in human malignant glioma cells depends on cellular density, algorithms of drug delivery and chemo/radio treatment. Vimentin and detyrosinated microtubules provide structural support for the extensive microtentacles observed in detached tumor cells and a mechanism to promote successful metastatic spread. Primary colorectal carcinomas display aberrant expression of vimentin, and have activated Notch and TGFbeta signaling pathways. Vimentin is a strong arterial substrate for transglutaminases. Transglutaminase-mediated vimentin dimerization results in a novel unifying pathway by which vasodilatory and remodeling responses may be regulated. Ablation of vimentin expression inhibits migration and invasion of colon and breast cancer cell lines. Vimentin is the main intermediate filament protein in mesenchymal cells and is therefore of value in the differential diagnosis of undifferentiated neoplasms.
Synonyms:Vimentin, Vim, FLJ36605.
Storage Buffer:For periods up to 1 month store at 4°C, for longer periods of time, store at -20°C. Prevent freeze thaw cycles.

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