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Vimentin Monoclonal Antibody, FITC [hVimentin] (CPAB0497)

SKU:
CPAB0497
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Universal
Host Species:
Mouse
Isotype:
IgG1
Clone:
hVimentin
Applications:
IHC
$971

Description

system_update_alt Datasheet

Vimentin Monoclonal Antibody, FITC [hVimentin] (CPAB0497)

The Vimentin Antibody FITC (CPAB0497) is a valuable tool for researchers studying vimentin, an intermediate filament protein important for maintaining cell structure and function. This polyclonal antibody is raised in rabbits and is highly reactive with vimentin in human samples. Validated for use in various applications, including immunofluorescence and flow cytometry, this antibody enables precise detection and analysis of vimentin in different cell types.Vimentin is known to be involved in processes such as cellular migration, adhesion, and signaling, making it a key player in cancer metastasis and invasion.

By targeting vimentin with this antibody, researchers can gain insights into the role of this protein in cancer progression and potentially identify new therapeutic targets for cancer treatment.Overall, the Vimentin Antibody FITC (CPAB0497) is a reliable tool for studies in cell biology, cancer research, and other fields where understanding vimentin's function and regulation is critical. Its specificity and versatility make it an essential component of any research program focused on vimentin biology.

Product Name:Vimentin Antibody, FITC
Product Sku:CPAB0497
Size:500μg
Host Species:mouse
Immunogen:Purified Human Vimentin.
Clone:hVimentin.
Reactivity:Other bodies
Applications:Immunohistochemistry
Purification Method:Ion exchange column.
Isotype:IgG1
Background:Vimentin expression in human malignant glioma cells depends on cellular density, algorithms of drug delivery and chemo/radio treatment. Vimentin and detyrosinated microtubules provide structural support for the extensive microtentacles observed in detached tumor cells and a mechanism to promote successful metastatic spread. Primary colorectal carcinomas display aberrant expression of vimentin, and have activated Notch and TGFbeta signaling pathways. Vimentin is a strong arterial substrate for transglutaminases. Transglutaminase-mediated vimentin dimerization results in a novel unifying pathway by which vasodilatory and remodeling responses may be regulated. Ablation of vimentin expression inhibits migration and invasion of colon and breast cancer cell lines.
Synonyms:
Storage Buffer:In lyophilized form, for long periods, store at 4°C in a dry environment. After reconstitution, if not intended for use within a month, aliquot and store at -20°C.

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